Biofilm Causes Cancer and Gum Spirits of Turpentine Cure it.

https://pmc.ncbi.nlm.nih.gov/articles/PMC10454087

Biofilm and Cancer: Interactions and Future Directions for Cancer Therapy

Euna Choi 1, Ben Murray 1, Sunga Choi 2,*

Editor: Carmine Stolfi

PMCID: PMC10454087 PMID: 37629016

Abstract

There is a growing body of evidence supporting the significant role of bacterial biofilms in the pathogenesis of various human diseases, including cancer.Biofilms are polymicrobial communities enclosed within an extracellular matrix composed of polysaccharides, proteins, extracellular DNA, and lipids. This complex matrix provides protection against antibiotics and host immune responses, enabling the microorganisms to establish persistent infections. Moreover, biofilms induce anti-inflammatory responses and metabolic changes in the host, further facilitating their survival. Many of these changes are comparable to those observed in cancer cells. This review will cover recent research on the role of bacterial biofilms in carcinogenesis, especially in colorectal (CRC) and gastric cancers, emphasizing the shared physical and chemical characteristics of biofilms and cancer. This review will also discuss the interactions between bacteria and the tumor microenvironment, which can facilitate oncogene expression and cancer progression. This information will provide insight into developing new therapies to identify and treat biofilm-associated cancers, such as utilizing bacteria as delivery vectors, using bacteria to upregulate immune function, or more selectively targeting biofilms and cancer for their shared traits.

Microb Pathog

. 2022 May:166:105530. doi: 10.1016/j.micpath.2022.105530. Epub 2022 Apr 13.

Characterization of Turpentine nanoemulsion and assessment of its antibiofilm potential against methicillin-resistant Staphylococcus aureus

Abderrahmen Merghni 1, Mohamed Ali Lassoued 2, Bakoliarisoa Nivomalala Voahangy Rasoanirina 2, Sarra Moumni 2, Maha Mastouri 3

Affiliations Expand

PMID: 35429586 DOI: 10.1016/j.micpath.2022.105530

Abstract

Turpentine essential oil (TEO) is a commercially available product having application as food additive, due to its ethno-botanical and ethnopharmacological properties. In the present study, we performed chemical composition of TEO by Gas Chromatography-Mass Spectrometry (GC-MS). Further, TEO was nanoemulsified, encapsulated and characterized by droplet size, PDI, Zeta potential and transmittance. The obtained turpentine nanoemulsion (TNE) was investigated for its antibacterial and antibiofilm potentiality against methicillin-resistant Staphylococcus aureus (MRSA), a model biofilm-forming microorganism. Small micellar TEO nanoparticles were succesfully formed with a mean droplet size ranging from 22.52 to 26.54 nm. Thermodynamic stability studies revealed homogeneous dispersion of the droplets size confirming the stability of TNEs. The developed nano-emulsions displayed two fold enhanced antagonistic activity against S. aureus in comparison with TEOs, with minimum inhibitory concentration (MIC) values at 0.039% (v/v) against MRSA. Additionally, TNEs displayed potent antibiofilm activity against MRSA strains with percent biofilm disruption of around 70.83%. Findings from this study validates the phytomedicinal significance of turpentine nanoemulsions and envisage its exploration as a natural and cost-effective strategy against bacterial biofilms in medical and industrial sectors.

https://pubmed.ncbi.nlm.nih.gov/35429586/

Anon used it, can confirm it works and could not believe how effective it is. I take a tablespoon of sugar+a teaspoon of GST+a teaspoon of castor oil at the start of almost every day now