Common drugs taken by millions of pregnant women linked to autism in children
Anti-inflammatory drugs taken by millions of pregnant women around the world may raise the risk of autism in their babies.
A study looked at the impact on children who are exposed to glucocorticoids - a class of steroids - in the womb.
Those prenatally exposed to the drugs were between 30 and 50 percent more likely to be diagnosed with autism compared to children whose mothers did not take them.
The study also linked glucocorticoids - which include prednisone and cortisone - to a higher risk of intellectual disabilities, Attention-deficit/hyperactivity disorder (ADHD) and anxiety.
Researchers looked at the development of more than 1 million infants born between 1996 and 2016.
Of the 1.1 million children, more than 300,000 were exposed to glucocorticoids in the womb.
The risk of intellectual disabilities and ADHD was 30 percent higher in the exposed group of children.
And mood, anxiety, and stress-related disorders were 50 percent higher.
For the children of mothers with autoimmune or inflammatory disorders, the risk of autism and ADHD was 30 percent higher in the exposed group, while mood problems and intellectual disabilities were 40 percent higher.
https://www.dailymail.co.uk/health/article-14247795/Anti-inflammatory-drugs-pregnant-women-linked-autism.html
January 3, 2025
Mental Disorders Among Offspring Prenatally Exposed to Systemic Glucocorticoids
Question: Is prenatal exposure to systemic glucocorticoids associated with subsequent mental disorders?
Finding: In this Danish population-based cohort study of 1,061,548 infants comparing exposed vs unexposed offspring born to mothers with similar underlying disease, prenatal exposure to systemic glucocorticoids was associated with higher risk of some mental disorders.
In this population-based cohort study, we examined the association between prenatal exposure to systemic glucocorticoids and mental disorders in offspring, including autism spectrum disorders, intellectual disabilities, ADHD, and mood, anxiety, and stress-related disorders. On the basis of previous animal and human studies, we hypothesized that prenatal exposure is associated with mental disorders later in life.
https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2828648?
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