Nicotina Rustica has an entire medical system built around it in South America with Maestro Tabaquero as the Doctors, it is seldom smoked and juiced or eaten for different medical goals.
“Tobacco Is the Chief Medicinal Plant in My Work”: Therapeutic Uses of Tobacco in Peruvian Amazonian Medicine Exemplified by the Work of a Maestro Tabaquero
https://pmc.ncbi.nlm.nih.gov/articles/PMC7576958/