Lift Weights or Get Experimental Gene Therapy?
(lb) >>22732647 Inside the secret island where wealthy people go to alter their DNA & extend life
Following its initial trial, the company claimed follistatin gene therapy 'increased lean mass, decreased fat, decreased inflammation, lengthened telomeres, and dramatically reversed epigenetic age acceleration'.
Obviously strength training helps build muscle (lean mass). [Eat to support the gains.]
More muscles burn more calories (decrease fat).
Lean body mass equals body weight minus body fat
https://en.wikipedia.org/wiki/Lean_body_mass
Let's clear it up, once and for all: all muscle is lean.
https://www.menshealth.com/fitness/a45865001/lean-muscle/
Use strength training to help ward off chronic disease
This type of exercise may protect you against chronic inflammation, diabetes, heart disease, and cancer. 01 Jul 2022
https://www.health.harvard.edu/staying-healthy/use-strength-training-to-help-ward-off-chronic-disease
Telomere Length and Biological Aging: The Role of Strength Training in 4814 US Men and Women
The findings showed that adults who strength trained regularly had significantly longer telomeres and therefore less biological aging than adults who did not strength train, even after taking into account many factors, including their age, sex, race, income, household size, smoking, body size, and participation in physical activities other than strength training.
30 Oct 2024
https://pmc.ncbi.nlm.nih.gov/articles/PMC11591842/
Strength training may reduce biological age by up to eight years, study finds
https://www.msn.com/en-us/health/fitness-and-exercise/strength-training-may-reduce-biological-age-by-up-to-eight-years-study-finds/ar-AA1vFZOK
If anon were to opine: 8 years seems like an understatement
Effects of Physical Exercise on Telomere Length in Healthy Adults: Systematic Review, Meta-Analysis, and Meta-Regression
analysis suggested that high-intensity interventional exercise significantly increased telomere length compared with the control intervention in healthy individuals
09 Jan 2024
https://pmc.ncbi.nlm.nih.gov/articles/PMC10806448/
Physical exercise and exercise trigger numerous changes and metabolic adaptations in the organism, resulting in an improvement in functional capacity and health, as well as decreasing the risk of developing metabolic or chronic diseases.
Indeed, some of these metabolites may serve as a substrate to allow epigenetic modifications in skeletal muscle, enabling transcriptional changes to key signaling pathways, and ultimately, muscle adaptation and remodeling.
exercise is a powerful tool for altering gene expression profiles in skeletal muscle by epigenetic modifications
07 Jan 2022
https://pmc.ncbi.nlm.nih.gov/articles/PMC8773693/
Resistance exercise in humans induced epigenetic changes in pathways associated with energy metabolism and insulin sensitivity, contributing to healthy skeletal muscle. Endurance exercise also caused modifications in biomarkers associated to metabolic alterations through changes in DNA methylation and the expression of specific miRNAs.
However, both resistance and endurance exercise are necessary to obtain a better physiological adaptation and a combination of both seems to be needed to properly tackle the increasing prevalence of non-communicable pathologies.
23 Sep 2019
https://pmc.ncbi.nlm.nih.gov/articles/PMC6921698/
Our systematic review supports that exercise is a powerful tool to alter the gene expression profile of human skeletal through epigenetic mechanisms.
13 May 2019
https://pmc.ncbi.nlm.nih.gov/articles/PMC6557592/