“They are eating the cats” got so much media coverage. We need to get this to Trump and MAHA RFK, Jr., ASAP.

If Trump can get this fast tracked in the USA and worldwide, he will be a HERO for all cat owners and maybe even humans.

Kidney disease kills most cats.

We need to spread this so Trump picks it up and can get it everywhere in the media and encourage this injection be made available NOW in the USA.. Imagine going from they are eating the cats to we can save all the cats and they can realistically live to 30 years!!!!!!!

It has already been proven in Toyko, Japan.

America, Trump CAN DO THIS as he gets things done WARP SPEED? MAHA

MACHA

MAKE ALL CATS HEALTY AGAIN

IT IS NOT A VACCINE IT IS AN INJECTABLE MEDICINE THAT CURES KIDNEY DISEASE IN CATS AND soon humans as well !!!!!!!

significantly improving the condition of patients with severe kidney disease by mass-producing normal AIM protein outside the body and administering it as a drug. In particular, the development of AIM veterinary drugs for cats has progressed ahead of that for humans, and the timeline for practical application is now in sight.

Director Miyazaki, you are not a veterinarian, but a doctor who treats human illnesses, so why are you researching chronic kidney disease in cats?

While researching the immune system's mechanism for attacking bacteria and viruses that invade the human body, I noticed that AIM in the blood selectively eliminates "internal garbage" such as waste products generated by metabolism, and works to maintain health. AIM usually floats quietly in the blood, but when it finds internal garbage, it becomes activated and goes to "clean up" the garbage.

Since animals other than humans also have AIM, I investigated the blood of several animals and found that only cats do not have AIM activated, which sparked my interest. I felt strongly that both humans and cats suffer from chronic kidney disease, for which there is no effective treatment.

AIM

While researching the immune system's mechanism for attacking bacteria and viruses that invade the human body, I noticed that AIM in the blood selectively eliminates "internal garbage" such as waste products generated by metabolism, and works to maintain health. AIM usually floats quietly in the blood, but when it finds internal garbage, it becomes activated and goes to "clean up" the garbage.

Toru Miyazaki

Professor of the Graduate School of Medicine

By improving kidney function, can "AIM" double cats’ lifespan?

— Thinking outside the box to develop a "wonder drug" —

Nearly 10 million cats are kept in Japan, and many of them die of kidney disease. Since discovering 20 years ago the "AIM" protein which is found in the blood, Professor Miyazaki has been devoted to the research of this particular protein. Over the course of his research, it became apparent that AIM improves kidney function. He is now working on developing medication that may substantially extend the lifespan of cats.

Read all:

https://www.u-tokyo.ac.jp/focus/en/features/z1304_00039.html

https://iamaim.jp/en/media/

https://pafoundation.com/2016/02/16/dr-miyazaki/

https://www.nature.com/articles/srep35251

>>22739173

2020

https://www.u-tokyo.ac.jp/focus/en/features/z1304_00039.html

By improving kidney function, can "AIM" double cats’ lifespan?

— Thinking outside the box to develop a "wonder drug" —

Nearly 10 million cats are kept in Japan, and many of them die of kidney disease. Since discovering 20 years ago the "AIM" protein which is found in the blood, Professor Miyazaki has been devoted to the research of this particular protein. Over the course of his research, it became apparent that AIM improves kidney function. He is now working on developing medication that may substantially extend the lifespan of cats.

Toru Miyazaki

Professor of the Graduate School of Medicine

Professor Miyazaki, who graduated from the UTokyo Faculty of Medicine in 1986, was working at a hospital in Kodaira, Tokyo as a medical intern when he happened to pick up a specialist magazine. In it, there was an article about Professor Kenichi Yamamura of Kumamoto University, who was one of the first in Japan to create a transgenic and knockout (genetically modified) mouse. Seeing this, Miyazaki immediately thought, "I must go and study with this professor." Thereafter, he went to France and Switzerland to further deepen his research on immunology, and in Switzerland he discovered a new molecule at the renowned Basel Institute for Immunology. Upon verifying in vitro that this molecule has the function to impede the death of macrophages, a type of white blood cell, he himself named it AIM, which is an acronym for "apoptosis inhibitor of macrophage."

A chance exchange served as the key

AIM exists abundantly in blood and has a complex structure, with three domains in the shape of little balls connected to one another. It was during Miyazaki’s time as an associate professor at the University of Texas Southwestern Medical Center at Dallas that he ascertained its function inside the body. Until then, however much Miyazaki examined AIM in mice, nothing happened. He had been laboring away for six whole years with no data being produced, until one day he bumped into a man on university grounds and engaged in a conversation with him that nudged Miyazaki in the right direction. That man was Professor Joseph Goldstein, an authority on cholesterol metabolism and winner of the Nobel Prize in Physiology or Medicine in 1985 for his research in the field. Professor Goldstein’s words inspired Miyazaki to treat mice without AIM with a high-fat diet to fatten them up, by which he discovered that compared to fat mice with AIM, obesity and fatty liver were likely to worsen for those without the gene. "(Fattening the mice up) is something that wouldn’t even cross the mind of an immunology researcher, and I thought it sounded ridiculous. But I wasn’t finding anything otherwise, so I did it out of desperation. That led to the elucidation of the function of AIM." He says that at that time, he fully realized the need to tear down the walls separating academic disciplines in order to learn about illnesses.

"As someone who had been on the fast track to a successful career in immunology, I was so shocked when I learned that we cannot determine even one of the functions of a protein produced by cells of the immune system based on the knowledge of immunology alone."

Cont:

>>22739183

Cont:

Since returning to the University of Tokyo in 2006, Miyazaki shifted his research towards all kinds of illnesses with a focus on AIM, and has published a number of papers demonstrating how AIM responds to obesity, liver cancer, type 2 diabetes and chronic peritonitis. In 2016, his paper clarifying AIM’s involvement in cats’ kidney disease was published in Nature Medicine. Kidney disease is caused by dead cells piling up in the urinary tract that eventually block off the passageway, much like a clogged up drain pipe, leading to kidney damage. Miyazaki describes AIM as a sort of agent serving to unclog the pipe.

"When there is waste inside the body like dead cells, AIM goes to the problem area through the blood and flags exactly where the waste is. AIM itself does not dissolve problem cells; rather, other cells like macrophages come along to eat them." Around 2015, when Miyazaki went for a drink with a veterinarian friend, he spoke of the relationship between AIM and kidney disease, and his friend reacted with excitement. Most cats get kidney damage by the time they are five years old, and die around 15 due to kidney failure. The arrangement of amino acids in cats’ AIM is slightly different to that of humans, and it is genetically designed not to function, which is also a common trait in the AIM of other felines such as lions and tigers. Conversely, AIM in dogs and mice works fine, explains Miyazaki.

Thinking AIM could be used as a therapeutic treatment for cats, Miyazaki set up a start-up company in 2017 called L’Aimia. He is currently conducting research on mass-producing cultivated AIM produced by mammalian cells and refining it. He plans on starting clinical trials on cats in 2020, with the goal of commodifying the treatment by 2022.

Aside from administering the treatment as a preventative vaccine, it is expected to work on cats with declined kidney function as well, potentially increasing life expectancy from 15 years to 30 years according to Miyazaki. No side effects have been found. It is supposed that there might be a chance of antibody production making cats resistant to the drug, though such an issue has not been observed to date when tested in cats.

Using AIM to treat humans in the future

Miyazaki says he likes cats, but what drives him the most is his determination to meet the high expectations of cat owners. He also goes on to speak about a dear friend he lost during his medical intern days due to a terminal illness, and that she was a cat lover too.

"I believe that perhaps my friend is one of the reasons why I was destined to save cats – I wouldn’t have ever imagined myself focusing on cats otherwise. In reality, however, I have witnessed many people passing away due to incurable illnesses, so I feel strongly about eventually using AIM to treat people. That is the greatest motivation that is supporting my research right now."

Cont:

https://www.u-tokyo.ac.jp/focus/en/features/z1304_00039.html

Trump needs to be the HERO and save the cats.

Spread this.

>>22739173

>>22739183

>>22739188

Cats and medicine

Cont:

https://www.u-tokyo.ac.jp/focus/en/features/z1304_00039.html

What's AIM?

A apoptosis A Greek term meaning "falling off," here it is used to signify programmed cell death.

I inhibitor This means "something that stops or slows down an activity."

M macrophage A type of white blood cell that eats and digests foreign material inside the body.

AIM therefore is something that stops the death of macrophages

Life expectancies of cats are expected to increase if kidney disease, which is one of the leading causes of death in cats, can be treated.

What's AIM?

A apoptosis A Greek term meaning "falling off," here it is used to signify programmed cell death.

I inhibitor This means "something that stops or slows down an activity."

M macrophage A type of white blood cell that eats and digests foreign material inside the body.

AIM therefore is something that stops the death of macrophages.

Life expectancies of cats are expected to increase if kidney disease, which is one of the leading causes of death in cats, can be treated.

Text: Tomoko Otake

When the kidney is impaired (acute kidney injury), tubular epithelial cells die and peel off, blocking up the renal tubule. Kidney damage progresses unless the blockage has not improved, resulting in either death or chronic kidney failure. It can be seen that kidneys with acute kidney injury have an accumulation of AIM (brown) in the dead cells that are blocking up the renal tubule.

As seen in the diagram on the left, AIM that have dissociated from the pentamers move from blood to urine, and accumulate around the dead cells that block up the renal tubule in humans and mice at the time of kidney injury. This serves as a sign and the dead cells are ingested via phagocytosis and cleaned out by surviving epithelial cells. As a result, the blockage improves and the kidney recovers. Cat AIM, on the other hand, are so strongly bound to IgM that they do not dissociate, which makes them unable to be carried into the urine and therefore unable to accumulate around the dead cells. As a result, surviving epithelial cells cannot clean the dead cells, which means the blockage is untreated, and thus kidney function worsens.

Miyazaki is a classical music aficionado and has learned the piano and conducting. In his lab, there are photographs of the conductor Herbert von Karajan as well as one of the world-renowned pianist Krystian Zimerman when he was invited to UTokyo to do a recital and a panel discussion. Miyazaki sometimes toyed with the idea of leaving medical school to go to a music college, or of making a phone call to Seiji Ozawa begging to become his pupil. "I think treating illnesses and conducting music have much in common. There must be something inside everyone like a key that conducts the whole body in beautiful, orderly harmony. I have a feeling that that something is AIM."

Cat owners from every political side will agree this is a good thing.

Trump can make this happen WARP SPEED.

Save the cats.

Kidney disease takes out millions of cats and especially senior cats. Now they can have an injection, not a vaccine, that clears the pipes so to speak. Read all.

This needs to go viral so Trump and RFK, jr see it and get working with Japan and get this to America NOW.

The research is already done. And can lead to human kidney disease reversal possibly.

Trump can go from they are eating the cats to we are saving the cats.

HERO situation as millions own cats and will do anything to save their loved pet.

Trump would get so much positive coverage if he brings this to pass ASAP.

>Get this to Trump and RFK, jr.

This can be done NOW.

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>>22739225

https://www.u-tokyo.ac.jp/focus/en/features/z1304_00039.html

https://www.jiji.com/jc/article?k=2025020500909&g=soc

https://pafoundation.com/2016/02/16/dr-miyazaki/

https://www.jiji.com/jc/article?k=2025020500909&g=soc

https://iamaim.jp/en/media/

Japanese scientist develops treatment that can help cats live up to 30 years

Ryan General

Updated Thu, March 7, 2024 at 4:05 PM MST2 min read

A Japanese scientist has developed a treatment targeting chronic kidney disease (CKD) in cats, potentially extending their lifespan to 30 years.

Cats and kidney disease: Cats, with an average lifespan of just 15 years, face CKD as a major threat as it dramatically worsens their health, particularly in adults. Affecting nearly 30% of cats by the age of 10, CKD is a complex ailment that can ultimately lead to organ failure and death.

Understanding the problem: In 2015, Dr. Toru Miyazaki, an immunology specialist at the University of Tokyo, discovered a protein called apoptosis inhibitor of macrophage (AIM) that helps the kidneys flush out toxins using immunoglobin antibodies. While AIM is present in the blood of many animals, he noticed that the protein doesn't always function properly in cats. This prevents crucial waste removal in felines, making them susceptible to kidney failure.

Combating CKD: Fueled by his passion for cats, Miyazaki has dedicated years of research to developing the "AIM" injection, a treatment targeting the root cause of feline kidney disease.

Trending on NextShark: Asian restaurant slams influencer's request for free meal in exchange for exposure

Miyazaki's research faced a hurdle early in the process when COVID-19 stalled his funding. But in 2022, he shared his struggles with Jiji Press, sparking a wave of support from cat lovers worldwide. When donations totaling 300 million Japanese Yen ($2 million) poured in, he decided to resign from his university position and focus solely on developing the AIM treatment.

What's next: The "AIM" injection has shown promising results in ongoing clinical trials, exceeding expectations and even showing improvement in terminally ill cats, reported the Sankei Shimbun. Miyazaki's team is actively working to ensure the affordability of the medication, making this life-saving treatment accessible to all cat owners. The injection is expected to be commercially available by 2025.

Trending on NextShark: Japan expands free day care centers to all children

>>22739173

>>22739271

What's next: The "AIM" injection has shown promising results in ongoing clinical trials, exceeding expectations and even showing improvement in terminally ill cats, reported the Sankei Shimbun. Miyazaki's team is actively working to ensure the affordability of the medication, making this life-saving treatment accessible to all cat owners.

The injection is expected to be commercially available by February 5, 2025

Updated:

https://www.jiji.com/jc/article?k=2025020500909&g=soc

AIM cat medicine to be put to practical use - Calling for participation in survey - Interview with AIM Medical Research Institute Director Toru Miyazaki

https://nextshark.com/japanese-scientist-develops-treatment-cat-lifespan

https://www.u-tokyo.ac.jp/focus/en/features/z1304_00039.html

AI Overview

+8

Toru Miyazaki, a professor specializing in disease biology and immunology at the University of Tokyo, discovered the protein Apoptosis Inhibitor of Macrophage (AIM) and founded the company L'Aimia to develop AIM-based treatments, particularly for cats, with the aim of extending their lifespan and treating kidney disease.

Here's a more detailed look at Miyazaki's work:

Discovery of AIM:

Miyazaki discovered AIM, a protein present in the blood of many animals, which he found to be crucial in removing waste and dead cells from the body, particularly in the kidneys.

Feline AIM and Kidney Disease:

He found that AIM doesn't function correctly in cats, making them prone to kidney disease, and that AIM accumulation in dead cells can cause kidney damage.

L'Aimia and AIM-Based Treatments:

In 2017, Miyazaki founded L'Aimia to develop AIM-based treatments for cats, focusing on improving kidney function and potentially doubling their lifespan.

The Institute for AIM Medicine (IAM):

Miyazaki later left the University of Tokyo in 2022 and founded the Institute for AIM Medicine (IAM), a non-profit organization, to further research and develop AIM-based treatments.

Current Projects:

Miyazaki and IAM are currently working on developing an AIM-based drug for cats, and clinical trials for this drug are expected to begin soon.

AIM30:

Miyazaki's research has also led to the development of AIM30, a cat food and supplement designed to activate AIM and support kidney health.

Future Goals:

Miyazaki hopes to extend the use of AIM to treat human diseases as well, inspired by his late friend and co-worker who passed away from an incurable illness.

It's Out Of The Bag! Cats Might Soon Have 18 Lives | by Alyssa Suarez

Feb 3, 2024 — Miyazaki discovered Apoptosis Inhibitor of Macrophage, or AIM for short, in Switzerland — a protein that is present in many animals' blood. AIM claim…

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>>22739271

Your Cat Could Live Twice As Long

https://youtu.be/fTtOkPYcqI0

Interview with Dr. Toru Miyazaki

>>22739173

>>22739183

>>22739225

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>>22739325

Almost all cats get kidney disease

>>22739197

Our cats have this, they can be healed with this NOW.

Not by breeding problems.

It is a problem that affects MOST cats when senior.

>>22739173

What's AIM?

A apoptosis A Greek term meaning "falling off," here it is used to signify programmed cell death.

I inhibitor This means "something that stops or slows down an activity."

M macrophage A type of white blood cell that eats and digests foreign material inside the body.

AIM therefore is something that stops the death of macrophages.

>>22739173

>>22739325

>>22739325

>>22739325

>>22739325

>>22739325 listen watch

>>22739325

>>22739197 cat hater

>>22739354 cat hater

>>22739350

>>22739354

>>22739325 watch

>>22739173

What's AIM?

A apoptosis A Greek term meaning "falling off," here it is used to signify programmed cell death.

I inhibitor This means "something that stops or slows down an activity."

M macrophage A type of white blood cell that eats and digests foreign material inside the body.

AIM therefore is something that stops the death of macrophages.

Feline Kidney Disease and AIM: A New Hope and Treatment

https://youtu.be/pA86HMdp4tg

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>>22739429

>>22739173

>>22739183

>>22739188

>>22739271

>>22739325

>>22739337

>>22739429

https://japanbookbank.com/en/book/5734

Book

Jiji Press Publication Services,Inc.

Bookmark

The Day Cats Live to Be Thirty: Discovery of the Blood Protein 'AIM

Abstract

It is widely known that many of cats die from kidney disease. Even if cats are fed a low-sodium diet, kidney function will always decline with age. Until now, the cause of kidney disease in cats has been completely unknown.

However, Dr. Toru Miyazaki, the author of this book, discovered the blood protein called "AIM (Apoptosis Inhibitor of Macrophage)" and elucidated that cats suffer from kidney disease because AIM doesn't function properly.

Since AIM's malfunction leads to kidney disease, it naturally follows that supplementing AIM should prevent its onset. If this AIM medicine for cats have been developed, cats may live to be even 30 years old, twice the current average lifespan.

This is tremendous good news for cat lovers. Furthermore, AIM is expected to be effective not only for felines but also for humans, and to be used not only for kidney disease but also for Alzheimer's disease, autoimmune disease, and other diseases that have been said to be "incurable".

TABLE OF CONTENTS (tentative translation)

Introduction A Physician Take on the Challenge of Developing a Cat Drug

Prologue Resurrection from "One Week to Live"

Chapter 1 From Clinical to Basic Medicine

Chapter 2 My Training Period

Chapter 3 Encounter with the Mysterious Protein "AIM"

Chapter 4 "Incurable" Diseases and AIM

Chapter 5 "Garbage Cleaning" by AIM and Kidney Disease

Chapter 6 Feline Kidney Disease and AIM

Chapter 7 Administration of AIM to Cats with Kidney Disease

Chapter 8 Development of a Feline Drug

Chapter 9 Toward Clinical Trials

Chapter 10 COVID-19 and AIM

Author’s Information

Toru Miyazaki

President and Director of the Institute for AIM Medicine (IAM)

Graduated from the University of Tokyo School of Medicine in 1986. Joined the Third Internal Medicine Department of the University of Tokyo Hospital. After completing studies at Kumamoto University Graduate School, worked as a researcher at the Louis Pasteur University of Strasbourg/IGBMC (France) from 1992, Principal Researcher at the Basel Institute for Immunology (Switzerland) from 1995, Associate Professor at Center for Immunology at the University of Texas Southwestern Medical Center at Dallas (USA) from 2000, and served as a professor at the Graduate School of Medicine, University of Tokyo, from 2006 to 2022.

Since April 2022, he has been the President and Director of the Institute for AIM Medicine (IAM). In 1999, he discovered AIM and subsequently advanced his research, promoting AIM drug development for various diseases including kidney disease. During this time, he discovered that AIM is congenitally dysfunctional in cats, leading to the development of AIM-based veterinary medicine targeting kidney disease in cats.

Series/Label —

Released Date Aug 2021

Price ¥1,800

Size 127mm×188mm

Total Page Number 244 pages

Color Page Number 4 pages

ISBN 9784788717558

Genre Nonfiction / Humanities Documentary

Visualization experience NO

AI Overview

+1

Toru Miyazaki's book, "The Day Cats Live to Be Thirty: Discovery of the Blood Protein 'AIM'," details his research and development of a treatment for chronic kidney disease in cats, utilizing a protein called AIM, aiming to potentially extend their lifespan.

https://coleandmarmalade.com/2024/05/23/a-way-to-help-more-cats-everywhere-to-reach-age-30-yes-please/

there’s one thing we’d like to change about life with cats, it’s that we have to say goodbye too soon. We’d prefer them to be immortal, but in lieu of that, we’d settle for extending their lives well past the average 15 years. Wouldn’t it be every cat lover’s dream to spend more quality time together? Now, it looks like such a thing might be within the realm of possibility in many cases. A scientist from Japan is developing an injectable ‘AIM vaccine’ that could double some cats’ lifespans!

As we know, a few rare cats have been known to live to age 30, with the oldest verified cat who ever lived reaching 38, Crème Puff, from Austin, Texas. But soon, living to age 30 may be much more common.

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>>22739173

< Since AIM's malfunction leads to kidney disease, it naturally follows that supplementing AIM should prevent its onset. If this AIM medicine for cats have been developed, cats may live to be even 30 years old, twice the current average lifespan. This is tremendous good news for cat lovers. Furthermore, AIM is expected to be effective not only for felines but also for humans, and to be used not only for kidney disease but also for Alzheimer's disease, autoimmune disease, and other diseases that have been said to be "incurable".

>>22739271

>>22739271

>>22739271

>>22739173

This Cat Lived to 38 Years! Here Is What Their Owner Did

https://youtu.be/vpvVTOONndA