Presence of celiac disease epitopes in modern and old hexaploid wheat varieties: wheat breeding may have contributed to increased prevalence of celiac disease.
Overall, the presence of the Glia-α9 epitope was higher in the modern varieties.
Modern wheat varieties have been designed between 1980 and 1990.
The diversity in banding patterns was lower in the modern varieties, clearly indicating a reduced genetic diversity. This implies that non-diagnosed CD patients nowadays may encounter a less diverse set of gluten proteins than several decades ago.
https://pmc.ncbi.nlm.nih.gov/articles/PMC2963738/