tyb
please add tonotables
TYB
Found something VERY interesting. TY and o7 to the IG video for the tip on where to dig. I transcribed the document.
C_A declassified doc: BIOCHEMICAL RESEMBLANCE BETWEEN ENDOPARASITES AND MALIGNANT TUMORS
CENTRAL INTELLIGENCE AGENCY
INFORMATION FROM FOREIGN DOCUMENTS OR RADIO BROADCASTS
Country: USSR Date of Information: 1950
Subject: Scientific-Medicine Date Dist. 26 Feb 1951
How Published: Monthly Periodical
Where Published: Leningrad No. of Pages: 2
Date Published: Oct 1950
(Original) Language: Russian Supplement to Report [ redacted ] 50X1-HUM
Source Priroda, Vol XXXIX, No 10, pp 22-27.
THIS IS UNEVALUATED INFORATION
BIOCHEMICAL RESEMBLANCE BETWEEN ENDOPARASITES AND MALIGNANT TUMORS
Prof. V. V. Alpatov
Endoparasites and malignant tumors resemble each other in many respects by reason of similar conditions under which they grow and exist. This suggested long ago the idea in regard to the parasitic nature of tumors.
Parasitic worms which live in the intestines exhibit a pronounced anaerobic metabolism (1). They deposit in their bodies large quantities of glycogen. The accumulation of glycogen is one of the properties which they share with tumors. The tissues of both intestinal parasitic worms and cancer tumors belong to the amphibiotic euryoxybiotical-aerofermentor type (Th. Brand's terminology), i.e., they are characterized by a metabolism involving incomplete oxidations under aerobic conditions and are at the same time adapted to anaerobic conditions (2).
In 1958, H Mauss synthesized the alkylated aminoxanthone Myracyl D, which was found to be effective both against Bilharzia and malignant tumors (3). The guanine analog Guanozolo (5-amino-7-hydroxy-1-v-triazolo d pyrimidine) synthesized by G. Kidder (4) suppresses the synthesis of nucleic acids (or, to be more precise, purine derivatives) in infusoria which are unable to convert adenine into guanine as well as malignant tumors of mice. It is interesting that Guanzolo is an optically active compound having dextraratory activity.
In investigating the relative toxic effect of atebrin enanthiomorphs on various animals, the author of this article, together with O. K. Nastyukova (2) found that the majority of animals are more sensitive to levaratory atebrin. However, the following test objects proved to be more sensitive to dextrorotatory atebrin: Erlich's adenocarcinoma (a gland cancer of mice), species of mollusks the body of which is turned in a left-handed spiral, and nematodes which live as parasites in the intestine of frogs. Thus, tissues of malignant tumors and parasitic worms are distinguished from healthy tissue and from that of non- parasitic worms by an opposite reason to optical enanthiomorphs of atebrin.
There are reasons to believe that the specific biological characteristics of malignant tumor tissue and parasites comprise the following elements: (1) presence of specific antigens in both malignant tissue and parasites; (2) optical inversion of the reception of certain optically active compounds such as atebrin; and (3) peculiarities of purine metabolism in malignant tissue which are connected with the synthesis of nucleic acids, and subsequently, of nucleo-proteins that are important constituents of cell nuclei. One may assume that malignancy is closely connected with alterations of the chemical properties of protoplasm, specific properties of enzymes, and possibly peculiarities of the protein carriers of enzymes.
Under the circumstances, recent work on protein of malignant tumors which is being carried out in the USSR (5,6,7) assumes particular importance.
BIBLIOGRAPHY
V. V. Alpatov and O. K. Nastyukova, DAN SSSR, Vol LIX, No 6, 1948.
V. V. Alpatov and O. K. Nastyyukova, Byulleten' Moskovakogo Obshchestva Ispytaniya Prirody, No. 6, 1947.
O. Hackmann, R. Geonnert, and H. Mauss, Naturewissenschaften, No 1, 29, 1949.
G. Kidder, et al, Nature, Vol CIX, p 511, 20 May, 1949.
B. I. Zbarskiy, Vrachebnoye Delo, No 2-3, 1947.
I. B. Zbarskiy, Uspekhi Sovremennoy Biologii, Vol XXII, 219, 1946.
V. Orekhovich, Biokhimiya, No 5, 1940.
-END-
SANITIZED COPY APPROVED FOR RELEASE2011/09/14: CIA-RDP80-00809A000600380033-3
https://www.cia.gov/readingroom/docs/CIA-RDP80-00809A000600380033-3.pdf