BABY MONKEYS INJECTED WITH HUMAN VAX SCHEDULE DEVELOPED AUTISM
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The structural and functional CNS alterations identified here provide a model to study the impact of early environmental exposures on primate neurodevelopment. While, as a pilot study, the size of the study groups limits the strength of the conclusions that can be drawn, the use of statistical modeling and repeated measures contributed to the study’s power and increased the accuracy of the estimates. Volumetric analyses identified significantly greater total brain volume in exposed compared with unex- posed animals at both measured time points. These results raise the possibility that multiple vaccine exposures during the previous 3-4 months may have had a significant impact on brain growth and development. However, for the amygdala, volumetric and [11C]DPN binding differences between groups appeared to be a function of more recent vaccine exposures, the primary MMR vaccine and the DTaP and Hib boosters given between T1 and T2. The functional observations on the differential avidity of the amygdala for [11C]DPN after vaccine exposure are novel and require further study.
Interestingly, a rapid increase in total brain volume between 6 and 14 months is generally considered to be a consistent finding for many children with an Autism Spectrum Disorder (ASD) ( Piven et al. 1995, Courchesne et al. 2001, Sparks et al. 2002), although this effect may be age-related ( Courchesne et al. 2001, Aylward et al. 2002) and cannot be used as a biomarker for the disorder (Herbert 2005). An enlarged brain volume may be due to a failure in programmed cell death or ‘neuronal pruning’, a process which rids the brain of abnormally functioning neural connections and optimizes coordinated neural functioning (Huttenlocher and Dabholkar 1997). When pruning fails to function, as may be the case in ASD, brain size will increase and neural connectivity will be decreased (Hill and Frith 2003).
Neuropathological and neuroimaging studies of indi- viduals with an ASD, a condition in which social functioning is often severely impaired (Schultz 2005), have provided growing evidence of a central role for the amygdala (Amaral et al. 2008, Kleinhans et al. 2009).
Hewitson, L; Lopresti, B.J.; et al "Influence of pediatric vaccines on amygdala growth and opioid ligand binding in rhesus macaque infants: a pilot study," Acta Neurobiol. Exp. 2010, 70, 147-64
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