chelate | ˈkēˌlāt |
noun Chemistry
a compound containing a ligand (typically organic) bonded to a central metal atom at two or more points.
adjective Zoology
(of an appendage) bearing chelae.
verb [with object] Chemistry
form a chelate with.
derivatives
chelation | kēˈlāSHən, -ˈlāSH(ə)n | noun
chelator noun
origin
early 19th century: from chela1 + -ate2.
2L8
KeyL8
Interleukin 8
Mammalian protein found in humans
Interleukin 8
Summary
Interleukin 8 (IL-8 or chemokine (C-X-C motif) ligand 8, CXCL8) is a chemokine produced by macrophages and other cell types such as epithelial cells, airway smooth muscle cells and endothelial cells. Endothelial cells store IL-8 in their storage vesicles, the Weibel–Palade bodies. In humans, the interleukin-8 protein is encoded by the CXCL8 gene. IL-8 is initially produced as a precursor peptide of 99 amino acids which then undergoes cleavage to create several active IL-8 isoforms. In culture, a 72 amino acid peptide is the major form secreted by macrophages.
There are many receptors on the surface membrane capable of binding IL-8; the most frequently studied types are the G protein-coupled serpentine receptors CXCR1 and CXCR2. Expression and affinity for IL-8 differs between the two receptors (CXCR1 CXCR2). Through a chain of biochemical reactions, IL-8 is secreted and is an important mediator of the immune reaction in the innate immune system response.
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Stanford Encyclopedia of Philosophyhttps://plato.stanford.edu › entries › plato-timaeus
Plato's Timaeus - Stanford Encyclopedia of Philosophy
Oct 25, 2005 … The shape of the universe's body—a sphere—and the characteristics it possesses or lacks are all explained in terms of their