Many people will never listen to anything that references Q, 8ch, halfchan, jews, or anything even remotely out of the mainstream. Considering this, memes without any of these while still exposing enough of the shocking truth - and there is plenty - may have the widest appeal.
Then there are those that vote D but dislike HRC, or BHO, or both, but will reject anything outright that paints their "team" in a bad light. Focusing on individuals known to be bad actors and / or complicit in some memes - again, without any mention of Q, chans, (((them))), etc - could reach them.
And of course there are those at the bottom of the Bell Curve that will never listen to anything they dont already find agreeable. Learn to recognize them and move on, but remember it isn't their fault, they were born fucktards and just want to eat their glue in peace.