It is checked by creatinine levels like I said. Guaranteed 3 days, if she takes the liquid form. Over $100 a bottle. Shaklee is a pyramid system, you can't just order from them, they will give you a local representative who will order it for you. You can even sign up to be a vendor, because once people try some of their stuff, there is nothing like most of the products that they sell, all excellent, some exceptional, and this one is exceptional. Liquid Lea is also a great liquid multi-vitamin. When your on his stuff, you will understand value. Let us know how you do. Remember one drop will hook you, and 3 teaspoons in 3 day will bring creatinine levels down to normal, 4 if you are at over .50 failure.