AI Overview, from Google:
While acetaminophen (Tylenol)doesn't directly alter the MTHFR gene, its use can affect individuals with MTHFR mutations by depleting glutathione, a crucial antioxidant that helps detoxify the harmful metabolite NAPQI. This, in turn, can potentially worsen acetaminophen toxicity, particularly with high or chronic use. MTHFR mutations can also lead to increased homocysteine levels due to impaired methylation, and acetaminophen's demand on the methylation pathway may indirectly influence homocysteine, though more research is needed.
How Acetaminophen and MTHFR Intersect
Glutathione Depletion: Acetaminophen is processed in the liver, where it produces a toxic byproduct called NAPQI. Glutathione, an antioxidant, helps neutralize NAPQI.
MTHFR Mutation: People with MTHFR gene mutations may have reduced methylation capacity, which can limit their ability to produce enough glutathione.
Increased Risk: When someone with an MTHFR mutation uses acetaminophen, especially in high doses or chronically, their already limited glutathione production might not be enough to detoxify NAPQI, potentially leading to liver damage.
Homocysteine Levels: MTHFR mutations can cause elevated homocysteine levels. Acetaminophen's use of the methylation pathway for glutathione synthesis might indirectly increase homocysteine, potentially contributing to cardiovascular risks.
https://www.google.com/search?q=does+acitmenephen+affct+the+mfhtr+gene