Folinic Acid would be Leucorvin which is precription. If I understand correctly that would be for those who have the PR Alpha anitbodies. It is prescription only but the label is being changed to allow certain asd patients use it as a theraputic treatment.. Methylfolate is teh bio available version that your body can use directly. It is supposed to help those who have a MTHFR gene mutation that limits their processing of folic acid. On methyl folate recently(less than 2 weeks) I would say our ASD adult is calmer and a little bit more focused, but no wow communication yet.