https://x.com/NicHulscher/status/1976706513684062271
Nicolas Hulscher, MPH
@NicHulscher
🚨BREAKING STUDY: Intranasal Nano-Ivermectin Shrinks Brain Tumors by 70% Without Toxicity
Landmark preclinical study shows intranasal ivermectin nanocapsules safely shrink glioblastoma in animal models at doses lower than the approved human antiparasitic dose 👇
📍Rats with implanted glioblastoma tumors received intranasal nano-ivermectin for 10 days at 60 µg/day — a dose below the approved human antiparasitic level.
📉Tumor volume dropped by ≈70% compared to untreated controls (79 mm³ vs 254–277 mm³).
📉The treatment also reduced necrosis, edema, and vascular proliferation, indicating less invasive and aggressive tumors.
✅No toxicity was observed — normal liver, kidney, blood, and lung histology; body weight unchanged throughout treatment.
Other formulations — free ivermectin and silica-based particles — showed no significant tumor reduction, highlighting key role of nanocapsule delivery for brain targeting.
These findings align with ivermectin’s 14 distinct anti-cancer mechanisms summarized by Yuwen et al, encompassing inhibition of oncogenic signaling (YAP1, Wnt–TCF, Akt/mTOR, EGFR/NF-κB, MAPK), mitochondrial and oxidative-stress induction, ion-channel modulation, and suppression of both cancer stem cells and the epithelial–mesenchymal transition (EMT).
Clinical translation in humans is urgently needed.
Scientific journal cover from ACS Biomaterials Science and Engineering 2023 with title Intranasal Delivery of Ivermectin Nanosystems as an Antitumor Strategy and authors names. Left panel shows profile of human head with brain highlighted in blue and inset of nano-capsules as spherical structures. Right panel displays bar graph comparing tumor volumes in mm³ for groups: control at 254-277 mm³, IVM at similar levels, IVM-NC reduced to 79 mm³.
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Nicolas Hulscher, MPH
@NicHulscher
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Aug 5
🚨 STUDY – Ivermectin Shows Striking Anticancer Potential and Remarkable Safety
Largest review of ivermectin and cancer to date finds 14 distinct anticancer mechanisms — and no safety concerns ⬇️
✅ Signs of remission & tumor stability
✅ 36 cancer patients – NO serious x.com/MakisMedicine/…
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6:48 AM · Oct 10, 2025
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