Exosomes used in therapy are primarily derived from mesenchymal stem cells (MSCs), which can be sourced from various tissues. The most common sources include:
Adipose tissue – Exosomes from adipose-derived stem cells (ADSCs) are widely used due to the ease of harvesting fat tissue.
Bone marrow – Bone marrow-derived MSCs are a traditional source, known for their regenerative properties.
Umbilical cord – Umbilical cord mesenchymal stem cells (UCMSCs) are favored for their high yield and potent bioactive molecules.
Placental and amniotic tissues – These perinatal tissues provide immunomodulatory and regenerative exosomes.
Other sources – Exosomes can also be isolated from body fluids like blood, urine, and saliva, or from cultured cells in laboratories.
Exosome research is still in its early stages, and the FDA has not yet approved any exosome products. (FDA approval means the agency has determined through clinical trials that the product is safe and effective for its intended use). However, cosmetic products and ingredients (other than color additives) don’t need FDA approval before they go on the market, so you can find skin care serums and moisturizers with exosomes in them. Despite this, there are still laws and regulations brands must follow.
“Because cosmetic treatments do not require FDA approval to go to the market, there is no requirement for the topical product to be proven as an effective treatment,” says NYC cosmetic dermatologist Dr. Michele Green. In fact, the FDA issued a warning in 2020 against regenerative medicine products, specifically products containing stem cells and exosomes, because people are commonly misled about their efficacy.
Any skin care brand can sell products with exosomes, since skin care isn;t required to have FDA approval; To ensure any topical you’re applying or buying is actually safe, always use a reputable brand that’s clear about its ingredients and where it sources them, says Green.
https://www.nbcnews.com/select/shopping/exosomes-skin-care-rcna206299