https://www.jci.org/articles/view/190034

Curing autoimmune diabetes (type I / type 1) in mice with islet and hematopoietic cell transplantation after CD117 antibody-based conditioning

Abstract

Mixed hematopoietic chimerism after allogeneic hematopoietic cell transplantation (HCT) promotes tolerance of transplanted donor-matched solid organs, corrects autoimmunity, and could transform therapeutic strategies for autoimmune type 1 diabetes (T1D). However, development of nontoxic bone marrow conditioning protocols is needed to expand clinical use. We developed a chemotherapy-free, nonmyeloablative (NMA) conditioning regimen that achieves mixed chimerism and allograft tolerance across MHC barriers in NOD mice. We obtained durable mixed hematopoietic chimerism in prediabetic NOD mice using anti–CD117 monoclonal antibody, T cell depleting antibodies, JAK1/2 inhibition, and low-dose total body irradiation prior to transplantation of MHC-mismatched B6 hematopoietic cells, preventing diabetes in 100% of chimeric NOD:B6 mice. In overtly diabetic NOD mice, NMA conditioning followed by combined B6 HCT and islet transplantation durably corrected diabetes in 100% of chimeric mice without chronic immunosuppression or graft-versus-host disease (GVHD). Chimeric mice remained immunocompetent, as assessed by blood count recovery and rejection of third-party allogeneic islets. Adoptive transfer studies and analysis of autoreactive T cells confirmed correction of autoimmunity. Analysis of chimeric NOD mice revealed central thymic deletion and peripheral tolerance mechanisms. Thus, with NMA conditioning and cell transplantation, we achieved durable hematopoietic chimerism without GVHD, promoted islet allograft tolerance, and reversed established T1D.

https://www.news-medical.net/news/20251118/New-transplant-approach-resets-the-immune-system-to-stop-Type-1-diabetes.aspx

New transplant approach resets the immune system to stop Type 1 diabetes

A combination blood stem cell and pancreatic islet cell transplant from an immunologically mismatched donor completely prevented or cured Type 1 diabetes in mice in a study by Stanford Medicine researchers. Type 1 diabetes arises when the immune system mistakenly destroys insulin-producing islet cells in the pancreas.

None of the animals developed graft-versus-host disease - in which the immune system arising from the donated blood stem cells attacks healthy tissue in the recipient - and the destruction of islet cells by the native host immune system was halted. After the transplants, the animals did not require the use of the immune suppressive drugs or insulin for the duration of the six-month experiment.

The possibility of translating these findings into humans is very exciting. The key steps in our study - which result in animals with a hybrid immune system containing cells from both the donor and the recipient - are already being used in the clinic for other conditions. We believe this approach will be transformative for people with Type 1 diabetes or other autoimmune diseases, as well as for those who need solid organ transplants."

Seung K. Kim, MD, PhD, the KM Mulberry Professor and professor of developmental biology, gerontology, endocrinology and metabolism

Kim, who directs the Stanford Diabetes Research Center and the Northern California Breakthrough T1D Center of Excellence, is the senior author of the study, which published online Nov. 18 in the Journal of Clinical Investigation. Graduate and medical student Preksha Bhagchandani is the lead author of the research.

https://www.erininthemorning.com/p/kansas-sends-letters-to-trans-people

Kansas Sends Letters To Trans People Demanding The Immediate Surrender Of Drivers Licenses

"The legislature did not include a grace period."

Today, transgender people across Kansas are reporting receiving letters from the Kansas Division of Vehicles stating that they must surrender their driver's licenses and that their current credentials will be considered invalid upon the law's publication in the Kansas Register on Thursday. Should any transgender person be caught driving without a valid license, they could face a class B misdemeanor carrying up to six months in jail and a $1,000 fine. Kansas already requires county jails to house inmates according to sex assigned at birth. The letter, obtained by Erin in the Morning, marks one of the most significant erosions of transgender civil rights in the United States to date.

The letter, which has been reported to Erin In The Morning by a Kansas-based activist, states that under House Substitute for Senate Bill 244, Kansas-issued driver's licenses and identification cards must now reflect the credential holder's “sex at birth.” It warns that upon the law's publication in the Kansas Register on Thursday, February 26, current credentials for affected individuals "will no longer be valid." The Legislature, the letter notes, "did not include a grace period for updating credentials," and anyone operating a vehicle without a valid credential "may be subject to additional penalties." Those whose gender marker does not match their sex assigned at birth are directed to surrender their current credential to the Division of Vehicles for reissuance.

You can see the full letter here:

SB 244, also known as the "bathroom bounty" bill, contained heavy identification document bans as well. The bill was rushed through the Kansas Legislature in January using a "gut and go" procedure that bypassed nearly all public input on its key provisions. Governor Laura Kelly vetoed the bill on February 13, calling it "poorly drafted," but the Legislature overrode her veto days later. In addition to the driver's license provisions, the law bans transgender people from using bathrooms matching their gender identity in public buildings and creates a bathroom bounty hunter system allowing citizens to sue transgender people they encounter in restrooms for at least $1,000 in damages, including potentially in private restrooms. The bill takes effect immediately upon publication in the Kansas Register rather than the standard July 1 effective date—giving transgender Kansans just days between the override and the invalidation of their identity documents.

The consequences for noncompliance could escalate quickly. Under Kansas law, driving without a valid license is a class B misdemeanor punishable by up to six months in jail and a $1,000 fine—though first-time offenders are more likely to face a citation and fine. A conviction, however, triggers an automatic 90-day license suspension. If a person drives during that suspension, they face a charge of driving on a suspended license, which carries a mandatory minimum of five days in jail. Kansas already requires county jails to house inmates by sex assigned at birth.

>>24313915

>irrational impulses

You mean no thinking and acting based on feels, including lying and cheating. Basically acting like retarded but also evil children.

>>24313940

>sex at birth

it's their actual sex. you can't change sex or gender or whatever you want to call it.

you can call yourself a beautiful woman, but that will never be the case, even you cut your balls off.

>>24313957

>everyone has said "what do you FEEL like doing tonite?"

No, "what do you want to DO tonite"

Also there is a juge difference between saying

>I want to eat pizza, just because I want to

and

>yes, you are a totally beautiful young lady, no, you are not a man, you really need to take that transgender surgery and these hormone pills, you are beautiful and are a legit female

The latter is literally evil, because they KNOW that what they are saying is nonsense, but they want that this someone basically castrates and then kills himself.

Or similar to women literally shaming men into going to war and getting blown up. Guess who they didn't shame. High ranking officers, who they fucked while their husbands were disfigured at the front lines. THAT IS EVIL. There is no way around it.

>emotional can be also be a kind of logic

no, it can't. It's nonsense.

for example some women are literally dreaming that you cheated on them and then ACT as if that ACTUALLY happened. That is fucking retarded and not good and also has nothing to do with logic at all. It's insanity.

>>24313967

>a [seemingly] legit legal defense

Look at current "courts".

That has always been a legit legal defense for women.

Go to family "court". Women can lie, cheat and whatever and basically never lose custody.

But as soon as the man acts angry - which is actually legit - it's used against him.

that's even the best playground for this kind of mental gymnastics.

>woman goal: get 100% custody, to get as much child support as possible

therefore anything helping her achieve this goal is legit. It doesn't matter how evil and vile it is.

>man goal: get access to his children

therefore anything that happens to HIM is accepted, even when it's complete nonsense.

And the "courts" are playing along, while pretending to be reasonable and following any kind of logic.

If they followed logic, they would lock these women up and remove custody, because you can't let insane people raise children. But instead the opposite happens in this upside-down world.

>>24313975

you are talking to yourself.

stop it.

>>24313986

>At some point in the womb an XX becomes

>an XY. (why men have nipples)

What

>it's like software

literally every cell in your body says "I'm a man".

>>24313989

t. was never getting divorce raped

>judges

are playing an evil and sick game.

>it's a choice

EXACTLY.

Some women CHOSE to lie and cheat. They know it's wrong, but they don't care, BECAUSE THERE ARE NEVER CONSEQUENCES FOR IT.

See w/ the war shaming. If they actually really meant it, they would shame everyone including themselves. But THEY don't want to lose limbs themselves. THEY don't want that chad officer loses limbs either. But undesirable men should go. That's the actual logic behind it, because in the end the "feels" argument is nonsense. There is actual rationality behind it when you actually think about it.

Take for example a woman who accuses a man of rape. Even when the man is very lucky and can PROVE that he is innocent, the man will still be seen as kind of guilty, while the woman will almost never get locked up anywhere, even when the male went to jail for years for these lies.

That's reality.

And the woman will get defended with lines like "but but if we lock her up, then that will hurt actual rape victims", which is hilarious and stupid and also makes no sense. They get off scott-free, and you wonder why the world is as shit as it is.

>>24313994

Oh, and that's also the case for leftists.

Deep down they know that it's lies and nonsense, OTHERWISE THEY WOULD ACCEPT trans-age and trans-race and whatever.

But they don't.

If you tell them, that you are trans-black and that's why you actually can wear dreadlocks, they will tell you that you are white and it's racist to have dreadlocks as a white person.

Same deal. If they actually believed the nonsense, they would have to accept all nonsense, at least the same kind of nonsense, but they don't.

Finally, Fuck Valve

https://www.pcgamer.com/gaming-industry/new-york-sues-valve-for-letting-children-and-adults-illegally-gamble-with-loot-boxes/

New York sues Valve for 'letting children and adults illegally gamble' with loot boxes

The lawsuit aims to "stop Valve from promoting gambling features in its games, disgorge all ill-gotten gains, and pay fines for violating New York’s laws."

New York state attorney general Letitia James announced on X and Bluesky today that the state of New York is opening a lawsuit against Valve for violating the state's gambling laws through its games.

In the brief post, James says Valve has "made billions of dollars by letting children and adults illegally gamble for the chance to win valuable virtual prizes. These features are addictive and harmful."

In a subsequent press release, the attorney general's office called out Counter-Strike 2, Team Fortress 2, and Dota 2 specifically.

"An investigation by the Office of the Attorney General (OAG) found that Valve’s video games, including Counter-Strike 2, Team Fortress 2, and Dota 2, enable gambling by enticing users to pay for the chance to win a rare virtual item of significant monetary value. In Valve’s most popular game, the process resembles a slot machine, with an animated spinning wheel that eventually rests on a selected item.

"The randomly selected virtual items have no in-game functionality but can be sold online for money, with one item reportedly being sold for more than $1 million. The lawsuit alleges that Valve has made billions of dollars luring its users, many of whom are teenagers or younger, to engage in gambling in the hopes of winning expensive virtual items that they can cash in on. With this lawsuit, Attorney General James seeks to permanently stop Valve from continuing to promote illegal gambling in its games and to pay disgorgement and fines."

https://bsky.app/profile/did:plc:j37zetcnytvnfjlk4ca3d2yv/post/3mfpjhohhes2e

New York Attorney General Letitia James

‪@newyorkstateag.bsky.social‬

Valve, a video game developer, has made billions of dollars by letting children and adults illegally gamble for the chance to win valuable virtual prizes.

These features are addictive and harmful.

That's why I'm suing to stop Valve’s unlawful conduct and protect New Yorkers.

>>24314044

https://swap.gg/blog/cs-reclaimed-4-billion

Counter-Strike Skin Market Reclaimed $4 Billion Market Cap

The Counter-Strike skin market has once again surpassed the $4 billion market cap, signaling a continued resurgence in the value of digital cosmetics within CS2. This milestone, tracked by Pricempire, highlights the growing demand for rare skins, knives, gloves, and sticker investments, despite market fluctuations over the past year.

With CS2’s competitive scene thriving and player engagement at an all-time high, the in-game economy continues to attract traders, collectors, and investors looking to capitalize on the rising value of digital assets.

CS2 Market Surpasses $4 Billion Again

According to the latest data, the total market cap for CS2 skins now sits at $4.1 billion, with a 3.28% increase in the past 24 hours. This growth comes after months of volatility, where prices saw significant dips following the market’s all-time high of $4.27 billion. However, recent trends suggest a strong recovery, with a 5.44% increase over the last 7 days, a 10.15% gain in the past 30 days, and a 12.20% surge over the past 90 days.

A Look at the CS2 Market Trends

The CS2 skin market has experienced several waves of growth and decline since the game’s full release. Several key events have influenced these market movements:

April - June 2023: Skin Boom Post-CS2 Announcement

Valve’s announcement and beta release of CS2 caused a major spike in skin prices, as players anticipated enhanced graphics and lighting effects on skins.

August - September 2023: Price Correction

After reaching peak highs, the market corrected, with some skins dropping in value as demand temporarily cooled off.

October 2023 - Present: Gradual Market Recovery

With consistent player engagement, a thriving esports scene, and major updates, skin prices have steadily climbed back up, culminating in the market reclaiming its $4 billion valuation.

Absolutely ridiculous. It's virtual non-existant shit.

>>24314113

sure, but that's a different matter.

at least you get the amount of fiat for whatever reason. It's not fucking gambling.

for example a child mows your lawn for $5. And the child gets $5 for that work. It doesn't matter that it's fiat, because the child will still get something for those $5 and there was no gambling involved.

In the case of Counter-Shit and these other games, it's literally gambling.

You insert a few dollars and then you press the button and it's literally a slot machine w/ the same mechanics as a slot machine. For example pretending that it was SUCH a close call for a $1000 skin. That way you gamble some more. And this crap is digital, so it's intentionally made this way.

If you want a specific skin, you can buy them but only on a so called "market", not from a store. And some are insanely expensive.

Meanwhile a free game like Fortnite is fair and square. You want skin X, you pay this amount (you can get the currency for literally free on top of that just by playing). and you get skin X.

No gambling involved.

>>24314124

>>24314125

In my opinion Valve should get forced to pay literally everything back.

They fucked over children and adults.

What they are doing is a casino business without a license, which is illegal in the real world.

That may break them, but who cares.

They started with "You won't own anything", so nothing of value would be lost.

>>24314148

>belief system

sure, you can call it that, but FIAT is "useful" so to speak, you can and should use it as a method of exchange, then it works and you won't pay extra.

Virtual cosmetics are not useful. But at least when you can directly buy them for a reasonable price, they may make sense.

>yet there it is? maybe "ban it" ?

it's gambling, therefore gambling rules should apply.

>parents involved

Why? A casino is also not allowed to let minors in, and in this case it's an unlicensed casino, therefore 100% illegal.

a casino is also supposed to make sure no one basically ruins their life, which Valve also doesn't do. They let minors into their casino, they don't care.

>>24314149

>not everywhere

casinos need a license basically everywhere.

and there are rules in all sorts of countries regarding gambling, for example don't let minors in.

In my opinion it should all get removed, but whatever.

>no rules are great

nope, also Valve is a US business, therefore US laws apply. Fuck Valve.