Scientists turn mosquitoes ‘into a vaccination tool’ to immunise bats against rabies
The insects are being designed to spread vaccines instead of disease 1/2
==Of course scientists thinks this a good idea, the same thing they did with Covid.)
blished 16 March 2026 2:09pm GMT
Mosquitoes typically spread disease, rather than prevent it, but Chinese scientists have proposed using the insects as an unlikely vector to deliver vaccines to bats.
In a study published in Science Advances journal, researchers designed mosquitoes which carry an immunisation for rabies and Nipah viruses within their saliva. This is transferred when bats eat insects, or the insects feed on the bats.
The proposal would solve a question many have grappled with: how do you vaccinate a flying mammal, which often roosts in caves in with millions of others, without exposing yourself to the diseases they carry?
Some consider this an important circle to square because bats host a wide range of dangerous pathogens – from Nipah and rabies to Ebola and some coronaviruses.As people encroach on their habitats, there are concerns that diseases are increasingly jumping into people and livestock. Vaccination could help to reduce transmission risk.
“Directly targeting bats, the natural reservoirs of these viruses, is crucial to preventing spillover events and mitigating public health risks,” the authors wrote in the paper, adding that traditional approaches have largely failed.
Experimental vaccines tested on captive bats haven’t worked effectively in wild populations, whileculling the mammals – which is practised in some regions to control rabies – has backfired. The disruption to colonies and the harm to ecosystems, plus the need for people to be in close contact with the bats to kill them, has instead increased virus transmission.
The Chinese research team created a vaccine based on a weakened version of vesicular somatitis virus (VSV), which can infect both insects and mammals and is already used in an approved Ebola vaccine made by Merck.
They then designed two innovative delivery methods to vaccinate bats against Nipah and rabies – which have fatality rates of up to 75 per cent and nearly 100 per cent, respectively.
In one route, researchers fed the Aedes aegypti mosquito blood containing the vaccine, which replicates inside the insect’s salivary glands. This means it is transferred when the insect bites the bat, or the bat eats the insects.
In experiments in the laboratory, both bats and mice exposed to the sterilised vaccine-carrying mosquitoes developed neutralising antibodies against both diseases.
The researchers also conducted a challenge trial for rabies – all of the animals exposed to the virus survived the lethal infection.They could not replicate this for Nipah as they did not have access to a high-level biosecurity laboratory, but said that the antibody levels in the vaccinated animals were similar.
https://archive.is/zwZyE#selection-3457.2-3523.182