https://my.clevelandclinic.org/health/treatments/ketamine-therapy
Ketamine Therapy
Medically Reviewed.Last updated on 01/16/2026.
Ketamine therapy uses a low dose of an anesthetic to treat depression, anxiety and some chronic pain. It works by blocking certain brain signals and helping nerve cells form new connections. It may quickly improve mood. Treatment is given by IV or nasal spray under medical supervision. You may need multiple sessions.