Meme resonance potential - The extent to which a particular meme resonates with a person and captures his or hers attention partially depends on the "base ground or the story setting, ie the imagery background and associated cultural knowledge content used by the meme.
For example, for someone who has never seen the American TV sitcom Seinfeld, a meme using one of the characters will not be very effective for they have no preestablished background information in order to process and understand the "meme".
Still, some memes such as Pepe, come out of nowhere and become extremely effective without requiring any prior info knowledge by the meme audience.