MetaAnalysis ish…23andMe

Genome-Wide Association Study of Male Sexual Orientation

We detected several promising regions of multiple SNPs in the 10−5–10−7 p-value range, as seen in the Manhattan plot (Fig. 1), though no SNP reached genome-wide significance (5 × 10−8). The most prominent of these regions were on chromosomes 13 (minimum p = 7.5 × 10−7, rs9547443) and 14 (p = 4.7 × 10−7, rs1035144), where some SNPs had 10−7 < p < 10−6 (each region with 9 to 10 SNPs with p < 10−5, Table S1). There are a number of genes of relevance to the trait in and around these regions, which we describe below. We further note that the most significant SNP (rs77013977, p = 7.1 × 10−8) in the 23andMe male GWAS29 was nominally associated (p = 4.1 × 10−3) in our own GWAS. We used a meta-analytic statistic that did not need direction of effect, Fisher’s combined probability test30, which yielded p = 6.7 × 10−9 for this SNP, which is the first reported genome-wide significant association for the trait. As previously noted29, rs77013977 is an intronic SNP in NKAIN3, which is one of a family of four proteins (NKAIN1–4) suggested to be critical for neuronal function31.

The strongest associated region on chromosome 13 (rs9547443, p = 7.5 × 10−7) was located between SLITRK6 (SLIT and NTRK like family member 6, ~60 kb centromeric to region) and SLITRK5 (~1.8 Mb telomeric), with SLITRK1 located ~2.0 Mb centromeric. Members of the SLITRK protein family are brain-expressed neuronal transmembrane proteins that regulate neuronal outgrowth, survival, and synapse formation; SLITRKs have significant homology to the secreted axonal growth-controlling SLIT family of proteins and also homology to the neurotrophic tyrosine kinase receptor (NTRK) family32–34. SLITRK6 is expressed especially in the diencephalon (which contains a region previously reported as differing in size in men by sexual orientation35), and SLITRK1 and SLITRK5 have their highest expression in the cerebral cortex32–34. Gene families, such as the SLITRK family that are important for neurodevelopment and are implicated as candidate genes for various neuropsychiatric phenotypes34, are also of potential relevance to behavioral phenotypes such as sexual orientation…

more here if you desire

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5721098/

>>4234335

if you knockout whole protein family it will lead to much more than gayness imo

>>4234470

u have me in tears man, i fell for some i admit but i learn. thank you guys

Isha Ambani wedding: Beyoncé and Hillary Clinton jet to India for nuptials

Celebrities including Beyoncé, Arianna Huffington, Sachin Tendulkar and Hillary Clinton have arrived in the Indian state of Rajasthan for the wedding of the daughter of country’s richest man.

Dozens of chartered planes flew into Udaipur for celebrations to mark the wedding of Isha Ambani and Anand Piramal, which has been dubbed locally “the big, fat Indian wedding”.

Ambani, 27, is the daughter of Reliance Industries chairman Mukesh Ambani, who is ranked by Forbes as India’s richest man. She will marry Piramal, 33, in the financial capital of Mumbai next Wednesday, but the celebrations began over the weekend in the city, with feasts, singing and dancing, and other pre-wedding rituals.

Ambani graduated from Yale in 2014 and has since joined the board of directors of two of the companies within her father’s Reliance empire. In 2015, Forbes named her as one of Asia’s women to watch.

The Clintons and the Ambanis have an association that goes back more than 18 years and have met several times both in India and abroad, according to Indian media reports. In March this year, when Hillary Clinton visited India to deliver a keynote speech at a conference in Mumbai, she dined with the Ambanis at their 27-floor Antilia residence – one of the world’s most expensive homes, according to local media.

https://www.theguardian.com/world/2018/dec/10/beyonce-hillary-clinton-isha-ambani-wedding-india?CMP=twt_gu

please dig on Bollywood stars, they def inz on power scheme…. follow the stars everywhere.

HRC present here.

ICE Arrests More Than 50 Illegal Immigrants In Raids Across New England

BOSTON – (News Release / ICE) — Officers from U.S. Immigration and Customs Enforcement’s (ICE) Enforcement and Removal Operations (ERO) Boston arrested 58 people in enforcement activities during a 5-day period, ending Dec. 4, in the New England region.

During the enforcement action, of the 58 individuals arrested by ICE’s ERO for violating U.S. immigration laws:

30 had prior felony convictions for serious or violent offenses;

33 have criminal charges pending;

15 individuals were previously released from local law enforcement custody, correctional facilities and/or court custody with an active detainer;

9 were referred for criminal prosecution to the appropriate U.S. Attorney’s Office in the jurisdiction; one is being referred to the U.S. Marshals for failure to register as a sex offender as required by federal law;

9 of those arrested had been previously removed from the United States and returned illegally; and,

4 had active Interpol Red Notices.

“The men and women of ICE, through efforts like the one we have completed this week, remain committed to apprehending dangerous criminal aliens who threaten our communities.” said Todd M. Lyons, Acting Field Office Director, ERO Boston. “ICE officers in New England continue to enforce immigration laws as they have always done, targeting criminal aliens and removing them from our streets. Despite unjustified criticism, our officers continue to work daily with professionalism and integrity to enforce immigration law and protect our communities from criminal aliens.”

Arrests include:

•In Lynn, Massachusetts, a 67 year-old national of Brazil who is wanted in Brazil for aggravated murder was arrested.

•In Putnam, Connecticut, a 59-year old national of Brazil who is wanted for murder in Brazil, a crime alleged to have been committed by casting a net over the victim and stabbing the victim 20 times, was arrested.

•In Methuen, Massachusetts, a 23- year old national of the Dominican Republic who had assumed the identity of a U.S. citizen with prior convictions for drug trafficking, identity theft, and resisting arrest, who is facing current pending drug trafficking charges.

•In Brockton, Massachusetts, a 41-year old national of France with previous convictions for cocaine possession and multiple instances of assault and battery whose history also includes 30 adult arrangements with arrestsfor kidnapping, assault and battery with a deadly weapon, domestic violence and other felony charges.

•In Windham, New Hampshire, a 44 year old national of Brazil wanted in Brazil for smuggling/embezzlement of firearms who had assumed the identity of a U.S. citizen, was arrested.

•In Hyannis, Massachusetts, a 41-year old Jamaican national convicted of possession of 28-100 grams of cocaine was arrested.

•In Dorchester, Massachusetts, a 40 year old national of the Dominican Republic with convictions for cocaine trafficking and money laundering was arrested.

Criminal histories of those arrested during the operation included charges and convictions for: Murder, Aggravated Identity Theft, Assault, Attempted Assault, Cocaine Possession, Cocaine Trafficking, Criminal, DUI and multiple other categories of crimes.

The arrestees include nationals from Dominican Republic, Brazil, France , Jamaica, Haiti and Antigua among other nations.

ICE focuses its enforcement resources on individuals who pose a threat to national security, public safety and border security. However, ICE no longer exempts classes or categories of removable aliens from potential enforcement. All of those in violation of immigration laws may be subject to immigration arrest, detention and, if found removable by final order, removal from the United States.

Some of the individuals arrested during this operation will face federal criminal prosecutions for illegal entry and illegal re-entry after deportation. The arrestees who are not being federally prosecuted, are detained in ICE custody, and will be processed administratively for removal from the United States. Any individual that returns to the United States illegally after being deported, is subject to immediate removal from the United States.

ICE places detainers on individuals who have been arrested on local criminal charges and who are suspected of being deportable, so that ICE can take custody of that person when he or she is released from local custody. When law enforcement agencies fail to honor immigration detainers and release serious criminal offenders onto the streets, it undermines ICE’s ability to protect public safety and carry out its mission.

https://breaking911.com/ice-arrests-more-than-50-illegal-immigrants-in-raids-across-new-england/

Bollywood is Satanic

Here are some of the many

Priyanka Chopra included

>>4234891

nice catch

>>4234959

sorry, passed me by