6-carboxytetrahydropterin synthase

From Wikipedia, the free encyclopedia

Jump to navigation

Jump to search

"CPH4" redirects here. For the fictional substance, see Lucy (2014 film).

6-carboxytetrahydropterin synthase (EC 4.1.2.50, CPH4 synthase, queD (gene), ToyB , ykvK (gene)) is an enzyme with systematic name 7,8-dihydroneopterin 3'-triphosphate acetaldehyde-lyase (6-carboxy-5,6,7,8-tetrahydropterin and triphosphate-forming).[1][2] This enzyme catalyses the following chemical reaction.

7,8-dihydroneopterin 3'-triphosphate + H2O ⇌ 6-carboxy-5,6,7,8-tetrahydropterin + acetaldehyde + triphosphate

This enzyme binds Zn2+. It is isolated from the bacteria Bacillus subtilis and Escherichia coli. The reaction is part of the biosynthesis pathway of queuosine. The enzyme from Escherichia coli can also convert 6-pyruvoyl-5,6,7,8-tetrahydropterin and sepiapterin to 6-carboxy-5,6,7,8-tetrahydropterin.[2]

References

Cicmil N, Shi L (February 2008). "Crystallization and preliminary X-ray characterization of queD from Bacillus subtilis, an enzyme involved in queuosine biosynthesis". Acta Crystallographica Section F. 64 (Pt 2): 119–22. doi:10.1107/s1744309108000924. PMC 2374184. PMID 18259064.

McCarty RM, Somogyi A, Bandarian V (March 2009). "Escherichia coli QueD is a 6-carboxy-5,6,7,8-tetrahydropterin synthase". Biochemistry. 48 (11): 2301–3. doi:10.1021/bi9001437. PMC 3227869. PMID 19231875.

External links

6-carboxytetrahydropterin+synthase at the US National Library of Medicine Medical Subject Headings (MeSH)

https://en.wikipedia.org/wiki/6-carboxytetrahydropterin_synthase