The Mad Hatter lost his marbles from Mercury poisoning. Mercury was used in working with felt.
Mercury poisoning symptoms fit a number of actors in this tragedy. Pelosi comes to mind first.
Symptoms and early signs of mercury poisoning.
Mercury may affect the nervous system, leading to neurological symptoms such as:
nervousness or anxiety
irritability or mood changes
numbness
memory problems
depression
physical tremors
As the levels of mercury in the body rise, more symptoms will appear. These symptoms may vary depending on a person's age and exposure levels. Adults with mercury poisoning may experience symptoms such as:
muscle weakness
metallic taste in the mouth
nausea and vomiting
lack of motor skills or feeling uncoordinated
inability to feel in the hands, face, or other areas
changes in vision, hearing, or speech
difficulty breathing
difficulty walking or standing straight
Mercury can also affect a child's early development. Children with mercury poisoning may show symptoms such as:
impaired motor skills
problems thinking or problem-solving
difficulties learning to speak or understanding language
issues with hand-eye coordination
being physically unaware of their surroundings
Mercury poisoning tends to develop slowly over time if a person comes into frequent contact with mercury.
https://www.medicalnewstoday.com/articles/320563.php