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Jewish Genetic diseases all cluster in pathways related to brain development.
Interesting theory: much like carriers of 1 allele for sickle cell enjoy immunity to malaria (heterozygous advantage) but those with both alleles suffer from sickle cell, carriers of 1 allele of Tay Sachs, gauchers, etc., have been shown to be of higher IQ, whereas those who inherit 2 are fuckt.
The theory is discussed here:
https://slatestarcodex.com/2017/05/26/the-atomic-bomb-considered-as-hungarian-high-school-science-fair-project/
Doctors have long noted that Ashkenazi Jews are uniquely susceptible to various genetic diseases. For example, they’re about a hundred times more likely to have Gaucher’s Disease, a hundred times more likely to get Tay-Sachs Disease, ten times more likely to have torsion dystonia, et cetera. Genetic diseases are so common in this population that the are official recommendation is that all Ashkenazi Jewish couples get screened for genetic disease before marriage. I’m Ashkenazi Jewish, I got screened, and I turn out to be a carrier for Riley-Day syndrome – three hundred times as common in Ashkenazi Jews as in anyone else.
Evolution usually gets rid of genetic diseases pretty quickly. If they stick around, it’s because they’re doing something to earn their keep. One common pattern is “heterozygote advantage” – two copies of the gene cause a disease, but one copy does something good. For example, people with two copies of the sickle cell gene get sickle cell anaemia, but people with one copy get some protection against malaria. In Africa, where malaria is relatively common, the tradeoff is worth it – so people of African descent have high rates of the sickle cell gene and correspondingly high rates of sickle cell anaemia. In other places, where malaria is relatively uncommon, the tradeoff isn’t worth it and evolution eliminates the sickle cell gene. That’s why sickle cell is about a hundred times more common in US blacks than US whites.
The moral of the story is: populations can have genetic diseases if they also provide a useful advantage to carriers. And if those genetic diseases are limited to a single group, we expect them to provide a useful advantage for that group, but not others. Might the Jewish genetic diseases provide some advantage? And why would that advantage be limited to Jews?
Most of the Jewish genetic diseases cluster into two biological systems – the sphingolipid system and the DNA repair system. This is suspicious. It suggests that they’re not just random. They’re doing something specific. Both of these systems are related to neural growth and neural branching. Might they be doing something to the brain?
Gaucher’s disease, one of the Ashkenazi genetic diseases, appears to increase IQ. CHH obtained a list of all of the Gaucher’s patients in Israel. They were about 15 times more likely than the Israeli average to be in high-IQ occupations like scientist or engineer; CHH calculate the probability that this is a coincidence to be 4×10^-19.