I've been digging on Adrenochrome and how it may relate to alcohol (for a future post). I've come across an interesting point on the chemical pathway that creates adrenochrome.
First an overview of the oxidation of Adrenochrome in vivo (in the body):
Adrenaline
>oxidizes to
Adrenochrome
>rapidly polymerizes to (making it unstable)
Adrenolutin
>further polymerization to
Melanin
It is common in biochemical pathways for the end products to regulate the pace of the pathway. This is achieved by higher products (in this case melanin) regulating enzyme kinetics from an early step.
"When there is sufficient melanin, tyrosine hydroxylase activity is low and less melanin is produced. That scheme of regulatory economy is typical of metabolism, as is most noted in the endocrine system, of which the neurotransmitters are a part." -https://archive.fo/gdkuC
So this all means to say when the body has high levels of melanin, it has an inhibitory effect on the production of more melanin.
The interesting aspect to all this is that the oxidation of adrenaline is NOT the only pathway to produce melanin. In fact, considering the spontaneous nature of adrenaline production (fight or flight) you can expect that other pathways are more ubiquitous.
"Naturally occurring melanin is formed through natural biochemical pathways which involve the hydroxylation and decarboxylation of the amino acids phenylalanine and tyrosine. In one possible anabolic pathway, tyrosine is hydroxylated to form the catecholamine dopa, which is 3,4-dihydroxyphenylalanine, then the diol is oxidized to form the diketone 3,4-dioxyphenylalanine (also known as dopaquinone). The dopaquinone is cyclized to form 5,6-indolequinones, and it is the polymerization of those indolequinones that produces melanin. There are alternative pathways for melanin production. However, in each of those alternatives an understanding of the mechanisms in the final steps remains elusive." -https://archive.fo/gdkuC
The above demonstrates that natural biochemical pathways for the production of melanin derive from the metabolism of TYROSINE and PHENYLALANINE. This is important because remember, excess melanin inhibits the conversion of tyrosine to it's intermediates that ultimately result in more melanin.
"But melanin production is more intimately involved with the neural system because TYROSINE and PHENYALALNINE are also the precursors for the neurotransmitters epinephrine, norepinephrine and dopamine." -https://archive.fo/gdkuC
So you have shared precursors for melanin and epinephrine (adrenaline). Humans that have MORE MELANIN, have an inhibitory effect on the production of early-step metabolization of TYROSINE. This means people with MORE MELANIN, when instigated to fight or flight, the metabolization of adrenaline from tyrosine is more readily able to occur ON DEMAND and to higher magnitudes due to the suppressed activity of tyrosine hydroxylase.
My hypothesis is this: People with darker skin pigment have a tendency in aggregate to be more susceptible to catastrophic adrenaline production when instigated through the fight or flight reaction.
This is supported by the russian fox domestication experiment where they selected the most docile fox (lowest susceptibility or production of adrenaline) from a litter to breed. Over time each generation drifted towards lighter color coats and varied melanin content (spots/stripes etc.). This implies that the inhibition of melanin production in darker coated foxes, due to higher melanin content, allowed for a higher magnitude, and more frequent adrenal response to external stimulation.
If the same is true for humans, i think we have our answer:
6 Mar 2018 - 1:06:24 PM
https://wikileaks.org/clinton-emails/emailid/629
So much is open source.
So much left to be connected.
Why are the children in Haiti in high demand?
How are they smuggled out?
‘Adoption’ process.
Local ‘staging’ ports friendly to CF?
Track donations.
Cross against location relative to Haiti.
Think logically.
The choice, to KNOW, will be yours.
Q
So if Haitian children produce bigger in magnitude adrenaline responses when instigated, consider the oxidation pathway of adrenaline to adrenochrome. Will you get more or less adrenochrome from Haitian children?
Oh, and major CF donor, 3M, holds a patent for mass producing stabilized adrenochrome. sauce: https://archive.fo/Al2Ho