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For we wrestle not against flesh and blood, but against principalities, against powers, against the rulers of the darkness of this world, against spiritual wickedness in high places.
Ephesians 6:12 King James Version (KJV)
Principalities are rulers that inherited their power, such as kings/queens, dynasties.
Powers are authorities that exert control over us by means of law and regulations, hierarchical power structures and the organs that they control such as police, courts.
Rulers of the darkness of this world are those at the top of satanic cults, illuminati families, etc.
Spiritual wickedness in high places would have to be the evil we have seen in the Catholic church and other denominations and religious organizations of all kinds.
My "definitions" above are just illustrations of what these words could mean, not by way of limitation or exclusion. I'm sure anons' imaginations can supply ample examples in each category.
We ARE in the time when our fight is not just against flesh and blood, but against dark spiritual forces who up until recently have maintained vicious control over the world.