Sanofi has exited it's position in MyoKarida
https://www.secform4.com/insider-trading/1552451.htm
This guy has been selling HARD.
Sardar Biglari (Persian: ; born August 30, 1977) is an American entrepreneur and is the founder, chairman and CEO of Biglari Holdings,[2] a holding company that trades on the New York Stock Exchange under the symbol BH. Biglari controls the Steak 'n Shake Company, First Guard Insurance, Maxim Magazine and the Western Sizzlin corporation among others, which are subsidiaries of Biglari Holdings.[3] Biglari is also founder, chairman and CEO of Biglari Capital, the general partner to The Lion Fund.
https://en.wikipedia.org/wiki/Sardar_Biglari
https://www.secform4.com/insider-trading/1067294.htm
they know the markets are pumped on low volume and are cashing out. Most of the insider sales are tied to compensation plans-that is a different thing and a different issue.
These types of these large sales represent them trying to get out before it falls apart imo.
This guy is a major player on wall street money wise.