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https://www.cellmedicine.com/wp-content/uploads/2017/07/Human-Umbilical-Cord-Mesenchymal-Stem-Cell-Therapy-for-Patients-with-Active-Rheumatoid-Arthritis-Safety-and-Efficacy.pdf
Human Umbilical Cord Mesenchymal Stem Cell Therapy for Patients, Study China
ClinicalTrials.gov identifier: NCT01547091
1: Cell Therapy Center, 323 Hospital of Chinese People's Liberation Army, 6 West Jianshe Road, Xi'an city, China
2: The State Key Laboratory of Experimental Hematology, Institute of Hematology and Hospital of Blood Diseases, Graduate School of Chinese Academy of Medical Sciences and Peking Union of Medical College, 288 Nanjing Road, Tianjin, China
3: Alliancells Institute of Stem Cells and Translational Regenerative Medicine of Zhongyuan Union Stem Cell Bioengineering Co Ltd, No.45 East Nine Road, Special Economic Zone of KongGang, Tianjin, China
4: Mingyuan Wu, Harold Hamm Diabetes Center and Section of Endocrinology and Diabetes in the Department of Internal Medicine, and Department of Physiology, University of Oklahoma Health Sciences Center, 941 Stanton L. Young Blvd., Oklahoma City, OK, 73104, USA
5: Mingyuan Wu and Yongjun Liu, School of Life Sciences and Technology, Tongji University, 1239 Siping Road, Shanghai, 200092, China
6: Mingyuan Wu, University of Oklahoma Health Sciences Center, 941 Stanton L. Young Blvd., Oklahoma City, OK 73104, USA
1: Liming Wang, Jianjun Zhou, Yang Li, Ming Li, Wen Bai, Bin Bai
2: Lihua Wang *
3: Xiuli Cong, Haijie Ji, Guangyang Liu, Delin Zhu
4&5: Mingyuan Wu 4,5,#
3&5: Yongjun Liu 3,5,#
https://www.cellmedicine.com/stem-cell-therapy-for-rheumatoid-arthritis/
The adult stem cells used to treat RA at the Stem Cell Institute come from human umbilical cord tissue (allogeneic mesenchymal).
These stem cells are expanded at Medistem Panama’s state-of-the-art laboratory.
The mesenchymal stem cells we use are recovered from donated umbilical cords following normal, healthy births. Each mother has her medical history screened and is tested for infectious diseases. Proper consent is received from each family prior to donation.
All umbilical cord-derived stem cells are screened for infectious diseases to International Blood Bank Standards before they are cleared for use in patients. Only a small percentage of donated umbilical cords pass our rigorous screening process.
Dr. Riordan on the Umbilical Cord Selection Process at Stem Cell Institute
“Through retrospective analysis of our cases, we’ve identified proteins and genes that allow us to screen several hundred umbilical cord donations to find the ones that we know are most effective. We only use these cells and we call them ‘golden cells’.
We go through a very high throughput screening process to find cells that we know have the best anti-inflammatory activity, the best immune modulating capacity, and the best ability to stimulate regeneration.”
Our mesenchymal stem cells and the US FDA: Are they approved?
Human umbilical cord tissue-derived mesenchymal stem cells (MSCs) that were isolated and grown in our laboratory in Panama to create master cell banks are currently being used in the United States under US FDA regulation.
These cells serve as the starting material for cellular products used in MSC clinical trials for two Duchenne’s muscular dystrophy patients under US FDA’s designation of Investigational New Drug (IND) for single patient compassionate use. (IND 16026 DMD Single Patient).
Will the patient reject this type of stem cell?
The body’s immune system is unable to recognize umbilical cord-derived mesenchymal stem cells as foreign and therefore they are not rejected. HUCT stem cells have been administered thousands of times at the Stem Cell Institute and there has never been a single instance rejection (graft vs. host disease).
As a matter of fact, allogeneic (not the patient’s own) mesenchymal stem cells are approved to treat graft vs. host disease in Canada and New Zealand.
Umbilical cord-derived mesenchymal stem cells also proliferate/differentiate more efficiently than “older” cells, such as those found in the fat and therefore, they are considered to be more “potent”.
https://www.cellmedicine.com/stem-cell-therapy-for-autism/
http://www.cellmedicine.com/wp-content/uploads/2012/11/Stem-Cell-Therapy-for-Autism.pdf
1: Medistem Laboratories Inc, Tempe, Arizona, USA
2: Institute for Cellular Medicine, San Jose, Costa Rica
3: Americas Medical Center, Ridgefield, Connecticut, USA
4: 2027 E. Cedar Street Suite 102 Tempe, AZ 85281, USAEm