If it's Warren.. no chance.
Many Democrats will be tarnished by DECLAS etc
There's a theory that a late entrant will emerge for the Dem ticket.
It could be that Warren acts as attack dog & foil for 12 months, before the palatable centrist/popular Dem steps in. (i.e. "Spygate was terrible, but no more Trump, let's put it all behind us")
Remember when POTUS was really good buddies with Rex Tillerson, McMaster and Gary Cohn.