If that is the chronic wasting disease, then the danger of contamination resides primarily in the brain tissue. Meat should be safe to harvest if the animal selected is in good health. The CDC errs on the side of caution and doesn't condone harvesting the meat if there is any question of infection. There are, to date, 0 known cases of transmission to humans. When you kill a deer, make sure it's healthy before you pul the trigger, and if you're in an area that is known to host deer with CWD, avoid touching the brain matter and be as clean and careful as you can when cleaning the animal.
https://www.cdc.gov/prions/cwd/index.html