Trans…really is a mental illness

(Transgender Denver student Alec McKinney id'd as 2nd gunman in STEM school shooting)

The successful treatment of a gender dysphoric patient with pimozide.

Abstract

OBJECTIVE:

The case is reported of a gender dysphoric patient who responded successfully to pharmacotherapy with pimozide.

CLINICAL PICTURE:

An adult male patient with a borderline learning disability presented with cross-dressing and a strong wish to undergo a sex change.

TREATMENT:

Supportive psychotherapy and pharmacotherapy with pimozide was tried.

OUTCOME:

There was an excellent response to pimozide 2 mg daily, with a cessation of both cross-dressing and the wish for sex reassignment. When, after 1 year, the dose was reduced to 1 mg daily, there was a rapid return of the cross-dressing and the wish for sex reassignment. An increase in the dose again led to a remission which has been maintained since then.

CONCLUSION:

Pharmacotherapy with pimozide should be considered in cases of doubtful gender dysphoria.

https://www.ncbi.nlm.nih.gov/pubmed/8839957

Pimozide

Pimozide (sold under the brand name Orap) is an antipsychotic drug of the diphenylbutylpiperidine class. It was discovered at Janssen Pharmaceutica in 1963. It has a high potency compared to chlorpromazine (ratio 50-70:1).

Pimozide acts as an antagonist of the D2, D3, and D4 receptors and the 5-HT7 receptor. It is also a hERG blocker.

schizophrenia

Similarly to other typical antipsychotics pimozide has a high affinity for the Dopamine D2 receptor and this likely results in its sexual (due to prolactin hypersecretion) and extrapyramidal side effects as well as its therapeutic efficacy against the positive symptoms of schizophrenia.

https://en.wikipedia.org/wiki/Pimozide