It's obviously just his way of being cocky, we know what a "show boat" Comey is.
It's just his way of saying "CIA WILL WIN!"
He has Virginia beating Villa in the championship. So he's saying "the CIA will be the one's to beat the villains (Trump Team).
If you go further, you will see other narratives. Xavier is on a tear, but then gets beat by Gonzaga, which to me since Georgetown isn't in the tournament, Gonzaga is used to stand for "the Jezuits". Then the Jezuits get taken out by white nationalists/southern militia of some kind (North Carolina) who ultimately get put down by the CIA (Virginia).
Xavier means "X" as in "X marks the spot" on a MAP. So we have to help Xavier to win, to beat the CIA.