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When the cost of the relationship exceeds the beneits to any concerned party.
Trump's election took a wrecking ball to the Clinton's pay for play. The Clinton's clearly assumed that Trump was going to bust them so they went all out with Collusion. It seems Sotero/Hitlery (purple garb during concession speech)/Kerry and a few others ran a shadow foreign policy during Side Show Bob's investigation. It looks like whatever they were promising NATO allies, IRAN, Russia, China etc expired with the conclusion of Side Show Bobs reports. The UK, and in some cases Austrailia have changed their tone towards POTUS. Merkel appears to behaving a slow motion emotional/physical breakdown every few days, Mexico caving to Trump sanctions, NK getting serious with POTUS as well as China. etc etc.
So clearly, all actors have a whole lot less to carrot and stick people with. While Obozo still has his Black Jesus creds, Hitlery only ever ruled with an iron fist. She's out of ammo.
WRT Jeffery Epstein, he certainly worked with the Clintons to lure people to the Honey Pot. Those on the fence going to a drug n sex fueled party on Epstein Island would certainly feel more comfortable that it was likely safe if Hill or Bill went along.
An interesting arragement, neither Bill nor Hill are vulnerable to standard JE blackmail. They couldn't care less if the other was fucking 9 year olds, and none of their associates would bat an eye either. It's the weakness of JE's honey pot. He can never go to the police. If he does he goes down, and evidence against the Clinton's might backfire. It's a MAD policy. So they worked together when convenient.
This got shakey for JE when he got popped. Even though he walked, his blackmail op/honey pot stopped operation. He could still continue blackmailing those already caught, but he couldn't afford to run the op anymore. Given the deal he made, he was still untouchable, but he was definately a liability. The opening of the case files, and the DOJ arrest have now scuppered the whole op. Blackmail victims smell blood and want revenge, likely talking to their expensive attorneys about cutting a deal for evidence on Epstein and his honey-pot customers. Those paying for dirt from his honey-pot are distancing themselves quickly. Most blackmail victims are just quaking in their boots. All that Epstein has left is to either go to prison for the rest of his life or drop a MOAB. Unfortunately for Epstein, the SDNY probably doesn't want to go after JE's victims, so the only thing SDNY wants is evidence on who else has access to the blackmail files and if they were using it. Game Theory says he who blabs first blabs best. We'll see just what kind of insurance JE has this time. But if he's walking the streets, he better know how to prevent Arkancide.