Synergistic co-administration of computationally optimized broadly reactive antigens for human and avian h5n1 influenza
https://patents.google.com/patent/US20190111126A1/en
Inventor
Ted Milburn Ross
Tim Alefantis
Donald Martin Carter
Christopher Austin Darby
Abstract
The present invention provides co-administration (e.g., immunogenic cocktail and/or prime-boost regimens) of computationally optimized H5N1 influenza hemagglutinin (HA) polypeptides that. Co-administration of the optimized H5N1 influenza hemagglutinin (HA) polypeptides facilitates synergistic neutralization of viral infection and provides for improved protective immunity (e.g., a broad reactive immune response) to multiple H5N1 influenza virus clades and strains.
https://patents.google.com/?inventor=Tim+Alefantis
Harold Kleanthous
Current Assignee Oregon Health Science University
Sanofi Pasteur Inc
https://patents.google.com/?inventor=Tim+Alefantis