As far as Michigan goes
Ann Arbor = University of Michigan
William Mayo, the serial killer HH Holmes, and and John Jacob Abel all went to UofM Medical School together
>Abel showed great interest in isolating pure form of internal gland hormones. The first work that led to his international reputation as a pharmacologist and biochemist was the isolation of epinephrine from adrenal medulla.
Holmes had the fucked up "hotel" which maximized fear in his victims
Then there's the NAMBLA connection to Ann Arbor/Youth Liberation
And the Finders association with Ann Arbor and General Science Corporation
And the Ann Arbor connection to the Oakland County child killings/North Fox Island