Fluoride exposure from infant formula and child IQ in a Canadian birth cohort
https://www.sciencedirect.com/science/article/pii/S0160412019326145
http://archive.is/IhvQ8
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Consumption of formula reconstituted with fluoridated water can lead to excessive fluoride intake.
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Breastfed infants receive very low intake of fluoride.
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We compared IQ scores in 398 children who were formula-fed versus breastfed during infancy.
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IQ scores were lower with higher levels of fluoride in tap water.
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The effect was more pronounced among formula-fed children, especially for nonverbal skills.
Methods
We examined 398 mother-child dyads in the Maternal-Infant Research on Environmental Chemicals cohort who reported drinking tap water. We estimated water fluoride concentration using municipal water reports. We used linear regression to analyze the association between fluoride exposure and IQ scores, measured by the Wechsler Primary and Preschool Scale of Intelligence-III at 3–4?years. We examined whether feeding status (breast-fed versus formula-fed) modified the impact of water fluoride and if fluoride exposure during fetal development attenuated this effect. A second model estimated the association between fluoride intake from formula and child IQ.
Results
Thirty-eight percent of mother-child dyads lived in fluoridated communities. An increase of 0.5?mg/L in water fluoride concentration (approximately equaling the difference between fluoridated and non-fluoridated regions) corresponded to a 9.3- and 6.2-point decrement in Performance IQ among formula-fed (95% CI: -13.77, -4.76) and breast-fed children (95% CI: -10.45, -1.94). The association between water fluoride concentration and Performance IQ remained significant after controlling for fetal fluoride exposure among formula-fed (B?=?-7.93, 95% CI: -12.84, -3.01) and breastfed children (B?=?-6.30, 95% CI: -10.92, -1.68). A 0.5?mg increase in fluoride intake from infant formula corresponded to an 8.8-point decrement in Performance IQ (95% CI: -14.18, -3.34) and this association remained significant after controlling for fetal fluoride exposure (B?=?-7.62, 95% CI: -13.64, -1.60).
Conclusions
Exposure to increasing levels of fluoride in tap water was associated with diminished non-verbal intellectual abilities; the effect was more pronounced among formula-fed children.