>>7864823

I think the reason for going dark back then was also about replacing Cloudflare before shtf, to get rid of them before they do.

But yeah, was surely fully controlled.

It was nice to be back on 4 in a way, on the other hand it made it obvious how 4 is controlled by clowns. Epstein breads on 4 were closed down all the time and a few weeks later were even made by clowns themselves, trying to stall any progress.

An Epstein black book to text project was in the work, but it was a nightmare to complete it because of bread deletions and shills.

On here black book to text project had none of these problems and was completed.

Immune discovery 'may treat all cancer'

https://www.bbc.com/news/health-51182451

http://archive.is/Vt8nP

A newly-discovered part of our immune system could be harnessed to treat all cancers, say scientists.

The Cardiff University team discovered a method of killing prostate, breast, lung and other cancers in lab tests.

The findings, published in Nature Immunology, have not been tested in patients, but the researchers say they have "enormous potential".

Experts said that although the work was still at an early stage, it was very exciting.

What have they found?

Our immune system is our body's natural defence against infection, but it also attacks cancerous cells.

The scientists were looking for "unconventional" and previously undiscovered ways the immune system naturally attacks tumours.

What they found was a T-cell inside people's blood. This is an immune cell that can scan the body to assess whether there is a threat that needs to be eliminated.

The difference is this one could attack a wide range of cancers.

"There's a chance here to treat every patient," researcher Prof Andrew Sewell told the BBC.

He added: "Previously nobody believed this could be possible.

"It raises the prospect of a 'one-size-fits-all' cancer treatment, a single type of T-cell that could be capable of destroying many different types of cancers across the population."

How does it work?

T-cells have "receptors" on their surface that allow them to "see" at a chemical level.

The Cardiff team discovered a T-cell and its receptor that could find and kill a wide range of cancerous cells in the lab including lung, skin, blood, colon, breast, bone, prostate, ovarian, kidney and cervical cancer cells.

Crucially, it left normal tissues untouched.

Exactly how it does this is still being explored.

This particular T-cell receptor interacts with a molecule called MR1, which is on the surface of every cell in the human body.

It is thought MR1 is flagging the distorted metabolism going on inside a cancerous cell to the immune system.

"We are the first to describe a T-cell that finds MR1 in cancer cells - that hasn't been done before, this is the first of its kind," research fellow Garry Dolton told the BBC.

…

>>7864914

Original sauce

https://www.nature.com/articles/s41590-019-0578-8

http://archive.is/IFta9

Genome-wide CRISPR–Cas9 screening reveals ubiquitous T cell cancer targeting via the monomorphic MHC class I-related protein MR1

Abstract

Human leukocyte antigen (HLA)-independent, T cell–mediated targeting of cancer cells would allow immune destruction of malignancies in all individuals. Here, we use genome-wide CRISPR–Cas9 screening to establish that a T cell receptor (TCR) recognized and killed most human cancer types via the monomorphic MHC class I-related protein, MR1, while remaining inert to noncancerous cells. Unlike mucosal-associated invariant T cells, recognition of target cells by the TCR was independent of bacterial loading. Furthermore, concentration-dependent addition of vitamin B-related metabolite ligands of MR1 reduced TCR recognition of cancer cells, suggesting that recognition occurred via sensing of the cancer metabolome. An MR1-restricted T cell clone mediated in vivo regression of leukemia and conferred enhanced survival of NSG mice. TCR transfer to T cells of patients enabled killing of autologous and nonautologous melanoma. These findings offer opportunities for HLA-independent, pan-cancer, pan-population immunotherapies.

Has anyone a membership with that site?

Would be interested in the rest.

Properly formatted, sorry bakes:

Immune discovery 'may treat all cancer'

https://www.bbc.com/news/health-51182451

http://archive.is/Vt8nP

A newly-discovered part of our immune system could be harnessed to treat all cancers, say scientists.

The Cardiff University team discovered a method of killing prostate, breast, lung and other cancers in lab tests.

The findings, published in Nature Immunology, have not been tested in patients, but the researchers say they have "enormous potential".

Experts said that although the work was still at an early stage, it was very exciting.

What have they found?

Our immune system is our body's natural defence against infection, but it also attacks cancerous cells.

The scientists were looking for "unconventional" and previously undiscovered ways the immune system naturally attacks tumours.

What they found was a T-cell inside people's blood. This is an immune cell that can scan the body to assess whether there is a threat that needs to be eliminated.

The difference is this one could attack a wide range of cancers.

"There's a chance here to treat every patient," researcher Prof Andrew Sewell told the BBC.

He added: "Previously nobody believed this could be possible.

"It raises the prospect of a 'one-size-fits-all' cancer treatment, a single type of T-cell that could be capable of destroying many different types of cancers across the population."

How does it work?

T-cells have "receptors" on their surface that allow them to "see" at a chemical level.

The Cardiff team discovered a T-cell and its receptor that could find and kill a wide range of cancerous cells in the lab including lung, skin, blood, colon, breast, bone, prostate, ovarian, kidney and cervical cancer cells.

Crucially, it left normal tissues untouched.

Exactly how it does this is still being explored.

This particular T-cell receptor interacts with a molecule called MR1, which is on the surface of every cell in the human body.

It is thought MR1 is flagging the distorted metabolism going on inside a cancerous cell to the immune system.

"We are the first to describe a T-cell that finds MR1 in cancer cells - that hasn't been done before, this is the first of its kind," research fellow Garry Dolton told the BBC.

…