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>The present invention provides a live , attenuated coronavirus comprising a variant replicase gene encoding polypro teins comprising a mutation in one or more of non - structural protein ( s ) ( nsp ) - 10 , nsp - 14 , nsp - 15 or nsp - 16 . The corona virus may be used as a vaccine for treating and / or preventing FOREIGN PATENT DOCUMENTS a disease , such as infectious bronchitis , in a subject .