Did some work on two-hit/priming years back - so am way out of date but yes, second time around can be the storm
Qs - what about nature article last week on remdesivir & chloroquine being effective in vitro?
Https:/www.nature.com/articles/s41422-020-0282-0.pdf
Thoughts on ACE-2?
One early post I read suggested diphenhydramine and ranitidine (which got recalled in autumn 2019)