dChan
Anonymous ID: d11e1b Feb. 25, 2020, 10:55 p.m. No.8252809   🗄️.is 🔗kun   >>2819

Hey POTUS, Nobiletin phosphorylates the protein encoded by the PER2 gene, marking it for destruction and helping to reverse jetlag. Just saying

 

Shitty oral absorption, but encased in a methylated-b-cyclodextrin it works very well.

Anonymous ID: d11e1b Feb. 25, 2020, 11:02 p.m. No.8252853   🗄️.is 🔗kun

>>8252838

PER2 gene encodes a protein that helps control circadian clock.

 

Way complicated, but it keeps you deep asleep after you fall asleep (my problem) and resets you back to the correct time zone very fast.

Anonymous ID: d11e1b Feb. 25, 2020, 11:04 p.m. No.8252863   🗄️.is 🔗kun   >>3066

Potent Effects of Flavonoid Nobiletin on Amplitude, Period, and Phase of the Circadian Clock Rhythm in PER2::LUCIFERASE Mouse Embryonic Fibroblasts.

 

Shinozaki A, et al. PLoS One. 2017.

 

Show full citation

 

Abstract

 

Flavonoids are natural polyphenols that are widely found in plants. The effects of flavonoids on obesity and numerous diseases such as cancer, diabetes, and Alzheimer's have been well studied. However, little is known about the relationships between flavonoids and the circadian clock. In this study, we show that continuous or transient application of flavonoids to the culture medium of embryonic fibroblasts from PER2::LUCIFERASE (PER2::LUC) mice induced various modifications in the circadian clock amplitude, period, and phase. Transient application of some of the tested flavonoids to cultured cells induced a phase delay of the PER2::LUC rhythm at the down slope phase. In addition, continuous application of the polymethoxy flavonoids nobiletin and tangeretin increased the amplitude and lengthened the period of the PER2::LUC rhythm. The nobiletin-induced phase delay was blocked by co-treatment with U0126, an ERK inhibitor. In summary, among the tested flavonoids, polymethoxy flavones increased the amplitude, lengthened the period, and delayed the phase of the PER2::LUC circadian rhythm. Therefore, foods that contain polymethoxy flavones may have beneficial effects on circadian rhythm disorders and jet lag.

 

PMID 28152057 [Indexed for MEDLINE] PMCID PMC5289493