The son of Isaac and Sophie (née Greenberg) Sackler, Polish Jewish immigrant Brooklyn grocer, Sackler attended Erasmus Hall High School in his native Brooklyn. Failing to get a Jewish-allotted place in any New York medical school, he sailed steerage to the UK in 1937 and, with the help of Glasgow's Jewish community, enrolled at Glasgow University's Anderson College of Medicine. After World War II began, he completed his degree at the Middlesex Hospital School of Medicine in London.
During the Korean war, he was an army psychiatrist in Denver, Colorado, before joining his brothers, Arthur and Mortimer, both newly graduated doctors, at the Creedmoor psychiatric hospital in New York City. The three became a moving force in the research and clinical outpatient department at Creedmore, which would become the Creedmore Institute for Psychobiologic Studies. During the 1950s the brothers undertook pioneering research into how alterations in bodily function can affect mental illness. This work contributed to a move away from treatments such as electric shock and lobotomy towards pharmaceutical solutions or psychoanalysis. The brothers acquired small pharmaceutical companies and worked on reviving them from 1952. Since the 1990s, Raymond and Mortimer, now deceased, owned Purdue Pharma, a large privately owned business with products including OxyContin[5].
He renounced his U.S. citizenship in 1974 and subsequently lived a flamboyant life in Europe, shuttling among residences in England, the Swiss Alps, and Cap d’Antibes.[6]
Using his fortune[7] from pharmaceuticals he became a generous donor to charitable causes worldwide.[8]