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United States Patent 7,220,852
Rota , et al. May 22, 2007
Coronavirus isolated from humans
Abstract
Disclosed herein is a newly isolated human coronavirus (SARS-CoV), the causative agent of severe acute respiratory syndrome (SARS). Also provided are the nucleic acid sequence of the SARS-CoV genome and the amino acid sequences of the SARS-CoV open reading frames, as well as methods of using these molecules to detect a SARS-CoV and detect infections therewith. Immune stimulatory compositions are also provided, along with methods of their use.
Inventors: Rota; Paul A. (Decatur, GA), Anderson; Larry J. (Atlanta, GA), Bellini; William J. (Lilburn, GA), Burns; Cara Carthel (Avondale Estates, GA), Campagnoli; Raymond (Decatur, GA), Chen; Qi (Marietta, GA), Comer; James A. (Decatur, GA), Emery; Shannon L. (Lusaka, ZM), Erdman; Dean D. (Decatur, GA), Goldsmith; Cynthia S. (Lilburn, GA), Humphrey; Charles D. (Lilburn, GA), Icenogle; Joseph P. (Atlanta, GA), Ksiazek; Thomas G. (Lilburn, GA), Monroe; Stephan S. (Decatur, GA), Nix; William Allan (Bethlehem, GA), Oberste; M. Steven (Lilburn, GA), Peret; Teresa C. T. (Atlanta, GA), Rollin; Pierre E. (Lilburn, GA), Pallansch; Mark A. (Lilburn, GA), Sanchez; Anthony (Lilburn, GA), Tong; Suxiang (Alpharetta, GA), Zaki; Sherif R. (Atlanta, GA)
Assignee: The United States of America as represented by the Secretary of the Department of Health and Human Services, Centers for Disease Control and Prevention (Washington, DC)
N/A (N/A)
Family ID: 38049542
Appl. No.: 10/822,904
Filed: April 12, 2004
Related U.S. Patent Documents
Application Number Filing Date Patent Number Issue Date
60465927 Apr 25, 2003
Current U.S. Class: 536/23.72; 435/235.1
Current CPC Class: A61K 39/215 (20130101); C07K 14/005 (20130101); C12N 7/00 (20130101); A61K 39/12 (20130101); C12N 2770/20021 (20130101); C12N 2770/20022 (20130101); C12N 2770/20034 (20130101)
Current International Class: C12N 15/50 (20060101); C12N 7/00 (20060101)
Field of Search: ;536/23.72 ;514/44 ;435/235.1,320.1
References Cited [Referenced By]
U.S. Patent Documents
2005/0181357 August 2005 Peiris et al.
Foreign Patent Documents
WO 2004/085633 Oct 2004 WO
WO 2004/092360 Oct 2004 WO
This application claims the benefit of U.S. Provisional Patent Application No. 60/465,927 filed Apr. 25, 2003, which is incorporated herein by reference in its entirety.
Claims
We claim:
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An isolated nucleic acid molecule consisting of the nucleotide sequence as set forth in SEQ ID NO: 1.
Description
STATEMENT OF GOVERNMENT SUPPORT
This invention was made by the Centers for Disease Control and Prevention, an agency of the United States Government. Therefore, the U.S. Government has certain rights in this invention.
FIELD OF THE DISCLOSURE
This invention relates to a newly isolated human coronavirus. More particularly, it relates to an isolated coronavirus genome, isolated coronavirus proteins, and isolated nucleic acid molecules encoding the same. The disclosure further relates to methods of detecting a severe acute respiratory syndrome-associated coronavirus and compositions comprising immunogenic coronavirus compounds.
BACKGROUND
The coronaviruses (order Nidovirales, family Coronaviridae, genus Coronavirus) are a diverse group of large, enveloped, positive-stranded RNA viruses that cause respiratory and enteric diseases in humans and other animals. At approximately 30,000 nucleotides (nt), their genome is the largest found in any of the RNA viruses. The genus Coronavirus includes at least 13 species which have been subdivided into at least three groups (groups I, II, and III) on the basis of serological and genetic properties
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