http://www.natap.org/2020/newsUpdates/020620_03.htm

Chloroquine, a widely-used anti-malarial and autoimmune disease drug, has recently been reported as a potential broad-spectrum antiviral drug.8,9 Chloroquine is known to block virus infection by increasing endosomal pH required for virus/cell fusion, as well as interfering with the glycosylation of cellular receptors of SARS-CoV.10 Our time-of-addition assay demonstrated that chloroquine functioned at both entry, and at post-entry stages of the 2019-nCoV infection in Vero E6 cells (Fig. 1c, d). Besides its antiviral activity, chloroquine has an immune-modulating activity, which may synergistically enhance its antiviral effect in vivo. Chloroquine is widely distributed in the whole body, including lung, after oral administration. The EC90 value of chloroquine against the 2019-nCoV in Vero E6 cells was 6.90 ?M, which can be clinically achievable as demonstrated in the plasma of rheumatoid arthritis patients who received 500 mg administration.11 Chloroquine is a cheap and a safe drug that has been used for more than 70 years and, therefore, it is potentially clinically applicable against the 2019-nCoV.

Treatment -

*Remdesivir might work, some hosps have seen improvement with it quite rapidly, marked improvement in 1-3 days. ARDS trajectory is impressive with it, pts improve much more rapidly than expected in usual ARDS.

24/

*Recommended course is 10d, but due to scarcity all hosps have stopped it when pt clinically out of the woods - none have cont >5d. May cause LFT bump, but interestingly (200s-ish) for a day or 2 then rapidly back to normal - suggests not a primary toxic hepatitis.

25/

Spanish doc on twitter said she felt vastly improved taking that malaria drug.

chloroquine

Remdesivir and Chloroquine

Breakthrough: Chloroquine phosphate has shown apparent efficacy in treatment of COVID-19 associated pneumonia in clinical studies.

https://www.ncbi.nlm.nih.gov/pubmed/32074550/

The coronavirus disease 2019 (COVID-19) virus is spreading rapidly, and scientists are endeavoring to discover drugs for its efficacious treatment in China. Chloroquine phosphate, an old drug for treatment of malaria, is shown to have apparent efficacy and acceptable safety against COVID-19 associated pneumonia in multicenter clinical trials conducted in China. The drug is recommended to be included in the next version of the Guidelines for the Prevention, Diagnosis, and Treatment of Pneumonia Caused by COVID-19 issued by the National Health Commission of the People's Republic of China for treatment of COVID-19 infection in larger populations in the future.

https://www.dailymail.co.uk/news/article-8113093/Two-experts-reveal-experimental-drug-helped-SAVE-American-coronavirus-patients.html

Have doctors found a coronavirus wonder drug? Two experts reveal how experimental antiviral remdesivir saved one woman who was in critical condition and helped 14 infected Diamond Princess passengers

https://www.ndtv.com/india-news/rajasthan-treats-coronavirus-patients-with-swine-flu-malaria-hiv-drugs-2195009

https://www.ncbi.nlm.nih.gov/pubmed/30055216

Drug repurposing of quinine as antiviral against dengue virus infection.

"Quinine inhibited DENV production of DENV by about 80% compared to untreated controls, while the other three drugs decreased virus production by only about 50%"

https://www.ncbi.nlm.nih.gov/pubmed/1470664

In vitro virucidal effects of Allium sativum (garlic) extract and compounds

"Garlic (Allium sativum) has been shown to have antiviral activity, but the compounds responsible have not been identified."

https://www.ncbi.nlm.nih.gov/pubmed/23123794

Fresh ginger (Zingiber officinale) has anti-viral activity against human respiratory syncytial virus in human respiratory tract cell lines

"Fresh ginger dose-dependently inhibited HRSV-induced plaque formation in both HEp-2 and A549 cell lines (p<0.0001)."

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6274093/

Curcumin Shows Antiviral Properties against Norovirus

"Among these phytochemicals, curcumin (CCM) was the most potent anti-noroviral phytochemical, followed by resveratrol (RVT). "

https://www.ncbi.nlm.nih.gov/pubmed/26403820

In Vitro Antiviral Activity of Cinnamomum cassia and Its Nanoparticles Against H7N3 Influenza A Virus.

"The silver nanoparticles derived from Cinnamon extract enhanced the antiviral activity and were found to be effective in both treatments, when incubated with the virus prior to infection and introduced to cells after infection."

https://www.ncbi.nlm.nih.gov/pubmed/24779581

Antiviral efficacy and mechanisms of action of oregano essential oil and its primary component carvacrol against murine norovirus.

"Under TEM, the capsids enlarged from ?35 nm in diameter to up to 75 nm following treatment with oregano oil and up to 800 nm with carvacrol; with greater expansion, capsid disintegration could be observed. "

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6817632/

Antibacterial and immunomodulator activities of virgin coconut oil (VCO) against Staphylococcus aureus

"The amount of high LA (40–60%) mainly in the form of free fatty acids and monoglycerides in coconut oil has antibacterial activity, antiviral, antifungal, antiprotozoal, and also can enhance the immune system. "

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5788933/

Antimicrobial activity of apple cider vinegar against Escherichia coli, Staphylococcus aureus and Candida albicans; downregulating cytokine and microbial protein expression

"The results demonstrate ACV has multiple antimicrobial potential with clinical therapeutic implications."

https://www.ncbi.nlm.nih.gov/pubmed/16540196

Virucidal efficacy of sodium bicarbonate on a food contact surface against feline calicivirus, a norovirus surrogate.

"Sodium bicarbonate at concentrations of 5% and above was found to be the most effective with 4 log(10) (99.99%) reduction in FCV titers on food contact surfaces within a contact time of 1 min. The virucidal efficacy of sodium bicarbonate was enhanced when it was used in combination with aldehydes or hydrogen peroxide. "

>>8435176

This is a shit show. I hate this.

>>8435176

Well, there's never been a virus before, I guess?

>>8435183

https://www.ncbi.nlm.nih.gov/pubmed/30055216

Drug repurposing of quinine as antiviral against dengue virus infection.

"Quinine inhibited DENV production of DENV by about 80% compared to untreated controls, while the other three drugs decreased virus production by only about 50%"

https://www.ncbi.nlm.nih.gov/pubmed/1470664

In vitro virucidal effects of Allium sativum (garlic) extract and compounds

"Garlic (Allium sativum) has been shown to have antiviral activity, but the compounds responsible have not been identified."

https://www.ncbi.nlm.nih.gov/pubmed/23123794

Fresh ginger (Zingiber officinale) has anti-viral activity against human respiratory syncytial virus in human respiratory tract cell lines

"Fresh ginger dose-dependently inhibited HRSV-induced plaque formation in both HEp-2 and A549 cell lines (p<0.0001)."

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6274093/

Curcumin Shows Antiviral Properties against Norovirus

"Among these phytochemicals, curcumin (CCM) was the most potent anti-noroviral phytochemical, followed by resveratrol (RVT). "

(Curcumin = Turmeric)

https://www.ncbi.nlm.nih.gov/pubmed/26403820

In Vitro Antiviral Activity of Cinnamomum cassia and Its Nanoparticles Against H7N3 Influenza A Virus.

"The silver nanoparticles derived from Cinnamon extract enhanced the antiviral activity and were found to be effective in both treatments, when incubated with the virus prior to infection and introduced to cells after infection."

https://www.ncbi.nlm.nih.gov/pubmed/24779581

Antiviral efficacy and mechanisms of action of oregano essential oil and its primary component carvacrol against murine norovirus.

"Under TEM, the capsids enlarged from ?35 nm in diameter to up to 75 nm following treatment with oregano oil and up to 800 nm with carvacrol; with greater expansion, capsid disintegration could be observed. "

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6817632/

Antibacterial and immunomodulator activities of virgin coconut oil (VCO) against Staphylococcus aureus

"The amount of high LA (40–60%) mainly in the form of free fatty acids and monoglycerides in coconut oil has antibacterial activity, antiviral, antifungal, antiprotozoal, and also can enhance the immune system. "

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5788933/

Antimicrobial activity of apple cider vinegar against Escherichia coli, Staphylococcus aureus and Candida albicans; downregulating cytokine and microbial protein expression

"The results demonstrate ACV has multiple antimicrobial potential with clinical therapeutic implications."

https://www.ncbi.nlm.nih.gov/pubmed/16540196

Virucidal efficacy of sodium bicarbonate on a food contact surface against feline calicivirus, a norovirus surrogate.

"Sodium bicarbonate at concentrations of 5% and above was found to be the most effective with 4 log(10) (99.99%) reduction in FCV titers on food contact surfaces within a contact time of 1 min. The virucidal efficacy of sodium bicarbonate was enhanced when it was used in combination with aldehydes or hydrogen peroxide. "

>>8435183

Q should talk to Trump and have him talk to the FDA and say "hey guys, I know that we've got all these rules that say that you can't say that something is "antiviral" unless you do testing that costs $50 Million, but we've got the kind of crisis that is causing a whole bunch of bad results right here right now, so, maybe we can somehow get the word out that these things have been proven effective with other viruses, allow the companies that make these things or sell these things, that might get more people to eat these things, to, perhaps flatten the curve or something, or just to keep them from getting sick and having to go to the doctor, maybe our economy won't collapse."

>>8435183

Q should talk to Trump and have him talk to the FDA and say "hey guys, I know that we've got all these rules that say that you can't say that something is "antiviral" unless you do testing that costs $50 Million, but we've got the kind of crisis that is causing a whole bunch of bad results right here right now, so, maybe we can somehow get the word out that these things have been proven effective with other viruses, allow the companies that make these things or sell these things, that might get more people to eat these things, to, perhaps flatten the curve or something, or just to keep them from getting sick and having to go to the doctor, maybe our economy won't collapse."

>>8435212

yes, and so does non drug antiviral treatments