Anonymous ID: 2cd100 March 16, 2020, 9:05 p.m. No.8445837   🗄️.is đź”—kun   >>5850 >>6096 >>6117 >>6206 >>6286

Effects of chloroquine on viral infections: an old drug against today's diseases

November 2003

 

We review the available information on the effects of chloroquine on viral infections, raising the question of whether this old drug may experience a revival in the clinical management of viral diseases such as AIDS and severe acute respiratory syndrome, which afflict mankind in the era of globalisation.

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Conclusions

At present it is difficult to answer the question of whether old chloroquine will be able to live a “second youth”. Due to its main effect—ie, raising endosomal pH—the drug has an exceptionally broad spectrum of antimicrobial activity that could be exploited in many infections. Results obtained in the prophylaxis of Q fever indicate that chloroquine/hydroxychloroquine can be successfully used in the clinical management of infections other than malaria. As regards viral diseases, what is clear is that the drug has antiviral and immunomodulatory effects that warrant particular consideration.

 

https://www.thelancet.com/journals/laninf/article/PIIS1473-3099(03)00806-5/fulltext