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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4728566/

Quercetin as an Antiviral Agent Inhibits Influenza A Virus (IAV) Entry

Natural products appear to be a major source of anti-influenza drug discovery and offer new prospects for influenza management [14,15,16,17,18]. Quercetin (3,3’,4’,5,7-pentahydroxyflavone) is one of the most ubiquitous flavonoids, and it is found in many Chinese herbs, vegetables and fruits, as well as red wine [19]. Numerous experiments have shown that quercetin exerts antiproliferative [20], antioxidative [21], antibacterial [22], anticancer [23] and antiviral [24] effects. Uchide et al. [25] found that quercetin could protect patients from dying from severe complications associated with the pandemic influenza A (H1N1) virus infection. However, the details of its anti-influenza mechanism remain to be elucidated. To account for this, we investigate potential inhibition mechanism of quercetin against the influenza virus and hope to develop a novel anti-IAV agent against the influenza virus.