Adrenochome/schizophrenia Article
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1968975/pdf/brmedj03004-0042c.pdf
The two most important hypotheses advanced are
(1) that chronic anxiety states may be due to an
inadequate adrenochrome supply which will result in a
high adrenaline/adrenochrome ratio, and (2) that the
phenomena of schizophrenia are due to the toxic effects
of taraxein which follow defective enzymic destruction
of this substance. Unfortunately, these ingenious
hypotheses have not been supported by the experimental work of other groups.
No oxidative pathway to adrenochrome and adrenolutin has been found in
metabolic studies with labelled adrenaline, and there
is insufficient evidence as yet to incriminate taraxein
as the causative factor in the schizophrenic process.