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Coronavirus cases spike as six people are
admitted to intensive care
He said: 'Our liberties and human rights need to be changed, curtailed, infringed — use whatever word you want.
'I am concerned about people not following the advice.
'There are still too many people being witnessed on our streets, in our bars, in our cafés, using the Tube, using our buses.'
The Mayor said he would be working from home, 'wherever possible', to 'set the best possible example' as he told Londoners to do the same.
Mr Khan added: 'The advice from the government is just advice, and I think that provides a mixed message.
'We may move to a situation where we move from advice to bans.
'I can't say this clearly enough. People should not be travelling by any means unless they absolutely must. The scientific advice on this is very clear.
'Londoners should be avoiding social interaction unless absolutely necessary, and this includes avoiding using the transport network.'
The mayor told the London Assembly that all residents of the capital should 'strictly follow' the official advice and added that he would be working from home as much as possible.
He said: 'We are clearly still in the early phase of this crisis but the spread of the virus is at a more advanced stage in London than in other parts of the country.
'This means that further measures will need to be introduced at the point at which they will have the biggest effect.
'I can assure Londoners that this is under constant review by the experts.'
Mr Khan also suggested transport in the capital could be scaled back even further.
It has already been announced that up to 40 stations which do not interchange with other lines could be closed while the Waterloo and City line and Night Tube services will not run from Friday.
But the Mayor of London said: 'I want to be clear now that the frequency of services is likely to continue to reduce, potentially very significantly, over the days and weeks ahead.
'We will do this in a way that makes sure essential workers can still get around and we will not reduce service levels so that the remaining trains and buses are crowded.'