Anonymous ID: 5a6dc4 March 20, 2020, 5:29 p.m. No.8495156   🗄️.is 🔗kun   >>5253 >>5360 >>5672

https://www.google.com/search?q=pubmed+%22endosomal+ph%22&ei=ol11XqX4Aa6xrgTM1KPABA&start=10&sa=N&ved=2ahUKEwil0ebfparoAhWumIsKHUzqCEgQ8NMDegQIDRA6&biw=1366&bih=654

 

that's a link to a google search. Pubmed and "endosomal pH"

 

hydroxychloroquine and the other quinine drugs work in part by raising the endosomal pH. This C19 requires a low endosomal pH and I'd guess that there are other viruses that also require a low, acid, pH.

 

We've been taking, also, about baking soda, how that's also antiviral, and raises blood pH.

 

I'm looking at those links, there are a lot of them, and maybe someone else would want to look at them, find something that I don't find.

 

Add quinine to that search you get

 

https://www.ncbi.nlm.nih.gov/pubmed/9080598

 

Efficacy of certain quinolines as pharmacological antagonists in botulinum neurotoxin poisoning.

 

"Although the mechanism of protection by these antimalarial agents is probably through the raising of endosomal pH, the possibility that some of these drugs could also act by inhibiting toxin-induced channel formation cannot be ruled out."

 

It would be great to find other things in pubmed that raise the endosomal pH. I would guess that things that raise the endosomal pH would cure this C19.

Anonymous ID: 5a6dc4 March 20, 2020, 5:38 p.m. No.8495253   🗄️.is 🔗kun   >>5320 >>5360 >>5566 >>5672

>>8495156

 

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4204995/

 

Inhibition of Influenza Virus Replication by Targeting Broad Host Cell Pathways

 

Furthermore, even though quinine had a higher EC50 than mefloquine, it was able to completely abrogate PR8 replication at a higher concentration, which was not the case for mefloquine. In general, compared to chloroquine, amodiaquine and quinacrine showed similar antiviral activities against influenza viruses. Interestingly amodiaquine was the most active against X-31, chloroquine was the most potent against PR8 whereas amodiaquine and quinacrine were more effective against the A(H1N1)pdm09 virus. Overall, among the new compounds tested, we demonstrated that amodiaquine is the most potent, followed by quinacrine, mefloquine, quinine, quinidine, and primaquine.

Anonymous ID: 5a6dc4 March 20, 2020, 5:43 p.m. No.8495320   🗄️.is 🔗kun

>>8495253

 

"Moreover, studies with the anti-malaria drug chloroquine, a weak base that inhibits endosomal acidification, have demonstrated its antiviral effects against influenza A and B viruses, Chikunguya virus, and the human immunodeficiency virus [21]–[24]. In addition, chloroquine also inhibits low pH-dependent proteases in the Golgi network that participate in the maturation of nascent viral proteins [25], [26]."

 

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4204995/

Anonymous ID: 5a6dc4 March 20, 2020, 5:52 p.m. No.8495423   🗄️.is 🔗kun

Anecdotal reports of clinical benefits derived from a related compound, i.e. quinine, date back to the Spanish influenza pandemic of 1918/19. However, it was not until last year that the anti-influenza virus effects of chloroquine at clinically achievable concentrations were studied, in view of a possible application of this drug in the clinical management of influenza [4,15]. Investigations still have to be done on this topic. For example, the mechanisms of orthomyxovirus inhibition by chloroquine have been uncertain at the clinically achievable concentrations adopted in the most recent studies [4,15], as well as the effects of chloroquine on field isolates, including avian strains potentially transmittable to humans.

 

We here report the results of an initial evaluation of susceptibility to chloroquine of human and avian influenza A viruses. Susceptibility to chloroquine appears to be dependent on the pH requirements of the viruses and the electrostatic potential of haemagglutinin subunit 2 (HA2), which is involved in virus/cell fusion. Accordingly, the antiviral effects are exerted at an early step of virus replication.

 

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1878474/

 

Different pH requirements are associated with divergent inhibitory effects of chloroquine on human and avian influenza A viruses

Anonymous ID: 5a6dc4 March 20, 2020, 6:05 p.m. No.8495566   🗄️.is 🔗kun

>>8495253

 

It is mainly used as fertilizer and a flavouring agent in some types of liquorice. It is the product from the reaction of hydrochloric acid and ammonia.

 

https://en.wikipedia.org/wiki/Ammonium_chloride

 

Ammonium chloride

 

Also RAISES PH.

 

Seems like this is closer to baking soda.