Anonymous ID: d5bd34 March 22, 2020, 5:28 a.m. No.8514849   🗄️.is 🔗kun   >>4859 >>4896

Just some of the alternate uses for Chloroquine.

 

No wonder POTUS is enthusiastic about it.

 

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https://www.eurekalert.org/pub_releases/2019-07/gmu-gmu072319.php

 

George Mason University breast cancer treatment patent licensed by Targeted Pharmaceuticals

 

The completed clinical trial demonstrated chloroquine as an anti-autophagy agent. Autophagy is cellular recycling; it is a natural process that disassembles unneeded or defective components, allowing the cell to make energy.

 

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5718030/

 

Repurposing Drugs in Oncology (ReDO)—chloroquine and hydroxychloroquine as anti-cancer agents

 

Chloroquine (CQ) and hydroxychloroquine (HCQ) are well-known 4-aminoquinoline antimalarial agents. Scientific evidence also supports the use of CQ and HCQ in the treatment of cancer. Overall, preclinical studies support CQ and HCQ use in anti-cancer therapy, especially in combination with conventional anti-cancer treatments since they are able to sensitise tumour cells to a variety of drugs, potentiating the therapeutic activity. Thus far, clinical results are mostly in favour of the repurposing of CQ. However, over 30 clinical studies are still evaluating the activity of both CQ and HCQ in different cancer types and in combination with various standard treatments. Interestingly, CQ and HCQ exert effects both on cancer cells and on the tumour microenvironment. In addition to inhibition of the autophagic flux, which is the most studied anti-cancer effect of CQ and HCQ, these drugs affect the Toll-like receptor 9, p53 and CXCR4-CXCL12 pathway in cancer cells. In the tumour stroma, CQ was shown to affect the tumour vasculature, cancer-associated fibroblasts and the immune system. The evidence reviewed in this paper indicates that both CQ and HCQ deserve further clinical investigations in several cancer types. Special attention about the drug (CQ versus HCQ), the dose and the schedule of administration should be taken in the design of new trials.

 

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https://www.sciencedaily.com/releases/2017/01/170117084050.htm

 

Malaria drug successfully treats 26-year-old brain cancer patient

 

After her brain cancer became resistant to chemotherapy and then to targeted treatments, 26-year-old Lisa Rosendahl's doctors gave her only a few months to live. Now a paper published January 17 in the journal eLife describes a new drug combination that has stabilized Rosendahl's disease and increased both the quantity and quality of her life: Adding the anti-malaria drug chloroquine to her treatment stopped an essential process that Rosendahl's cancer cells had been using to resist therapy, re-sensitizing her cancer to the targeted treatment that had previously stopped working. Along with Rosendahl, two other brain cancer patients were treated with the combination and both showed similar, dramatic improvement.