1999 Paper Linked LSD's Hallucinogenic Effect to Actually Inducing Higher Levels of Adrenochrome
We concluded that LSD did not act as an hallucinogen per se but that it induced an increase in the pro-duction of adrenochrome which was the hallucinogen. An individual who could not make enough adrenochrome would not be able to have the typical LSD reaction.
The Adrenochrome Hypothesis and Psychiatry
A. Hoffer, M.D. Ph.D. and H. Osmond, M.D.
The Journal of Orthomolecular Medicine Vol. 14, 1st Quarter 1999
http://www.orthomolecular.org/library/jom/1999/articles/1999-v14n01-p049.shtml