Antimalarial DMARDs are derived from the compounds qui-nine and cinchonine, originally isolated from the bark of the Peruvian cinchona tree. ..
https://www.sciencedirect.com/sdfe/pdf/download/eid/3-s2.0-B9780323054751500458/first-page-pdf
I'm limited to published research, but I did wind up with a kilo of CInchonine HCl for various reasons. Anyway, since my wife is a smoker (I quit suddenly in November after a voice in my head SCREAMED at me to stop immediately), so I am dosing us at around 600mg a day, along with Quinine from Tonic Water.
so, n=2 anecdotal as prophylactic measure, but it's better than just sitting here going braindead.